Germ cell tumors

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Germ cell tumors are relatively uncommon childhood tumors. Several interesting characteristics distinguish them from other tumors. (1) Abnormal migration of primordial germ cells results in the frequent occurrence of extragonadal germ cell tumors in children. (2) Serum markers exist to allow evaluation of extent of resection and development of recurrent tumor. (3) The introduction of modern chemotherapy including cisplatin, etoposide, and bleomycin has significantly improved survival of these children. Optimal therapy includes complete surgical resection, accurate histological examination, and selective use of chemotherapy. Mature and immature teratomas at any site and stage I testicular cancers are managed by observation alone, whereas all other tumors require chemotherapy.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalSeminars in Pediatric Surgery
Volume6
Issue number1
StatePublished - 1997

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Germ Cell and Embryonal Neoplasms
Teratoma
Drug Therapy
Neoplasms
Bleomycin
Testicular Neoplasms
Etoposide
Germ Cells
Cisplatin
Biomarkers
Observation
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Germ cell tumors. / Rescorla, Frederick.

In: Seminars in Pediatric Surgery, Vol. 6, No. 1, 1997, p. 29-37.

Research output: Contribution to journalArticle

Rescorla, F 1997, 'Germ cell tumors', Seminars in Pediatric Surgery, vol. 6, no. 1, pp. 29-37.
Rescorla, Frederick. / Germ cell tumors. In: Seminars in Pediatric Surgery. 1997 ; Vol. 6, No. 1. pp. 29-37.
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