Gestational age-dependent changes in circulating hematopoietic stem cells in newborn infants

D. Clapp, J. E. Baley, S. L. Gerson

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

In the fetus, hematopoietic stem cells originate in the yolk sac and are believed to be transferred to all other hematopoietic organs via the circulation. In humans, the time course of this transfer has not been systematically evaluated in viable premature infants. We examined the cord blood of 13 preterm (25 to 36 weeks of gestation) and 10 term (38 to 42 weeks of gestation) infants for pluripotent (mixed colony-forming unit - granulocyte, erythrocyte, macrophage, megakaryocyte), erythroid (burst-forming unit - erythroid, colony-forming unit - erythroid) and myeloid (colony-forming unit - granulocyte, macrophage) stem cells. A gestational age-dependent decrease in all lineages of circulating hematopoietic stem cells was noted (p <0.001). By 34 weeks of gestation, preterm infant cord blood had a similar concentration of circulating stem cells compared with that of term infants. This gestational age-dependent decrease in hematopoietic stem cells of all lineages supports the hypothesis of a blood-borne transfer of hematopoiesis that appears largely complete by 34 weeks of gestation. Infants born after less than 32 weeks of gestation have high levels of circulating hematopoietic stem cells that may reflect the active transfer of hematopoiesis from liver to bone marrow.

Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalJournal of Laboratory and Clinical Medicine
Volume113
Issue number4
StatePublished - 1989
Externally publishedYes

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Hematopoietic Stem Cells
Stem cells
Gestational Age
Erythroid Precursor Cells
Newborn Infant
Pregnancy
Hematopoiesis
Blood
Fetal Blood
Premature Infants
Macrophages
Stem Cells
Yolk Sac
Granulocyte-Macrophage Progenitor Cells
Megakaryocytes
Cell Lineage
Granulocytes
Fetus
Liver
Erythrocytes

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Gestational age-dependent changes in circulating hematopoietic stem cells in newborn infants. / Clapp, D.; Baley, J. E.; Gerson, S. L.

In: Journal of Laboratory and Clinical Medicine, Vol. 113, No. 4, 1989, p. 422-427.

Research output: Contribution to journalArticle

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