Gestational glucose intolerance modifies the association between magnesium and glycemic variables in mothers and daughters 15 years post-partum

Liana C. del Gobbo, Yiqing Song, Ronald J. Elin, Sara J. Meltzer, Grace M. Egeland

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3 Scopus citations


Background: Gestational diabetes mellitus (GDM) and low magnesium (Mg) intake and status are associated with an increased risk of type 2 diabetes. However, Mg homeostasis may be modified by GDM. We sought to determine if a history of GDM prospectively modifies associations between Mg and glycemic variables in mothers and their offspring. Methods: Plasma and dietary Mg, anthropometric, lifestyle and glycemic variables were assessed in mothers affected by GDM during 1989-1990, a comparative group of normo-glycemic women, pregnant during the same time period, and the 15-year-old, nondiabetic daughters of affected and unaffected pregnancies (n = 332). Multivariate regression analyses evaluated the cross-sectional association between plasma and dietary Mg with glycemic variables in mothers and daughters. Results: Plasma Mg was lower in mothers with a history of GDM in comparison to control mothers after adjustment for current type 2 diabetes, race and body mass index (0.90 ± 0.01 versus 0.96 ± 0.01 mmol/L; p = 0.002). Plasma Mg was significantly associated with insulin sensitivity and was inversely associated with fasting insulin in GDM mothers only (p<0.05). Plasma and dietary Mg were significantly inversely associated with glycated hemoglobin and fasting glucose, respectively, in nondiabetic teenage daughters. For fasting glucose, plasma Mg was inversely associated in GDM-born daughters only. Conclusions: Associations between plasma Mg and some glycemic variables may be stronger in mothers and offspring with a history of GDM.

Original languageEnglish (US)
Pages (from-to)54-63
Number of pages10
JournalMagnesium Research
Issue number2
StatePublished - Jul 1 2012



  • Diabetes
  • Gestational diabetes
  • Insulin resistance
  • Magnesium
  • Pregnancy

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

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