Ginkgo biloba extract increases ocular blood flow velocity

Hak Sung Chung, Alon Harris, Jóhannes Kári Kristinsson, Thomas A. Ciulla, Carol Kagemann, Robert Ritch

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


We evaluated a possible therapeutic effect of Ginkgo biloba extract (GBE) on glaucoma patients that may benefit from improvements in ocular blood flow. A Phase I cross-over trial of GBE with placebo control in 11 healthy volunteers (8 women, 3 men: Age; 34 ± 3 years, mean ± SE) was performed. Patients were treated with either GBE 40 mg or placebo three times daily orally, for 2 days. Color Doppler imaging (Siemens Quantum 2000) was used to measure ocular blood flow before and after treatment. There was a two week washout period between GBE and placebo treatment. Ginkgo biloba extract significantly increased end diastolic velocity (EDV) in the ophthalmic artery (OA) (baseline vs GBE-treatment; 6.5 ± 0.5 vs 7.7 ± 0.5 cm/sec, 23% change, p=0.023), with no change seen in placebo (baseline vs GBE-treatment; 7.2 ± 0.6 vs 7.1 ± 0.5 cm/sec, 3% change, p=0.892). No side effects related to GBE were found. Ginkgo biloba extract did not alter arterial blood pressure, heart rate, or lOP. Ginkgo biloba extract significantly increased EDV in the OA and deserves further investigation in ocular blood flow and neuroprotection for possible application to the treatment of glaucomatous optic neuropathy as well as other ischemic ocular diseases.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalJournal of Ocular Pharmacology and Therapeutics
Issue number3
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

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