Ginkgo biloba extract increases ocular blood flow velocity

Hak Sung Chung, Alon Harris, Jóhannes Kári Kristinsson, Thomas A. Ciulla, Carol Kagemann, Robert Ritch

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

We evaluated a possible therapeutic effect of Ginkgo biloba extract (GBE) on glaucoma patients that may benefit from improvements in ocular blood flow. A Phase I cross-over trial of GBE with placebo control in 11 healthy volunteers (8 women, 3 men: Age; 34 ± 3 years, mean ± SE) was performed. Patients were treated with either GBE 40 mg or placebo three times daily orally, for 2 days. Color Doppler imaging (Siemens Quantum 2000) was used to measure ocular blood flow before and after treatment. There was a two week washout period between GBE and placebo treatment. Ginkgo biloba extract significantly increased end diastolic velocity (EDV) in the ophthalmic artery (OA) (baseline vs GBE-treatment; 6.5 ± 0.5 vs 7.7 ± 0.5 cm/sec, 23% change, p=0.023), with no change seen in placebo (baseline vs GBE-treatment; 7.2 ± 0.6 vs 7.1 ± 0.5 cm/sec, 3% change, p=0.892). No side effects related to GBE were found. Ginkgo biloba extract did not alter arterial blood pressure, heart rate, or lOP. Ginkgo biloba extract significantly increased EDV in the OA and deserves further investigation in ocular blood flow and neuroprotection for possible application to the treatment of glaucomatous optic neuropathy as well as other ischemic ocular diseases.

Original languageEnglish
Pages (from-to)233-240
Number of pages8
JournalJournal of Ocular Pharmacology and Therapeutics
Volume15
Issue number3
StatePublished - Jun 1999

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Ginkgo biloba
Blood Flow Velocity
Placebos
Ophthalmic Artery
Therapeutics
Optic Nerve Diseases
Eye Diseases
Therapeutic Uses
Glaucoma
Cross-Over Studies
Healthy Volunteers
Arterial Pressure
Color
Heart Rate

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Ophthalmology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Chung, H. S., Harris, A., Kristinsson, J. K., Ciulla, T. A., Kagemann, C., & Ritch, R. (1999). Ginkgo biloba extract increases ocular blood flow velocity. Journal of Ocular Pharmacology and Therapeutics, 15(3), 233-240.

Ginkgo biloba extract increases ocular blood flow velocity. / Chung, Hak Sung; Harris, Alon; Kristinsson, Jóhannes Kári; Ciulla, Thomas A.; Kagemann, Carol; Ritch, Robert.

In: Journal of Ocular Pharmacology and Therapeutics, Vol. 15, No. 3, 06.1999, p. 233-240.

Research output: Contribution to journalArticle

Chung, HS, Harris, A, Kristinsson, JK, Ciulla, TA, Kagemann, C & Ritch, R 1999, 'Ginkgo biloba extract increases ocular blood flow velocity', Journal of Ocular Pharmacology and Therapeutics, vol. 15, no. 3, pp. 233-240.
Chung HS, Harris A, Kristinsson JK, Ciulla TA, Kagemann C, Ritch R. Ginkgo biloba extract increases ocular blood flow velocity. Journal of Ocular Pharmacology and Therapeutics. 1999 Jun;15(3):233-240.
Chung, Hak Sung ; Harris, Alon ; Kristinsson, Jóhannes Kári ; Ciulla, Thomas A. ; Kagemann, Carol ; Ritch, Robert. / Ginkgo biloba extract increases ocular blood flow velocity. In: Journal of Ocular Pharmacology and Therapeutics. 1999 ; Vol. 15, No. 3. pp. 233-240.
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