Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT

Jin Huang, Lei Qiu, Li Ding, Shaozhan Wang, Jing Wang, Quangang Zhu, Fengyu Song, Jinhong Hu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ginsenoside Rb1 (GRb1) and paeoniflorin (PF) are active substances of Chinese traditional herbs and have been commonly used to treat skin inflammation diseases, but little is known about the mechanisms involved. In the present study, the effects of GRb1 and PF on the production of inflammatory mediators and the possible mechanisms of transient receptor potential vanilloid-1 (TRPV1) in these mediators induction were explored. It has been shown that GRb1 and PF inhibited the productions of IL-8 and PGE2 induced by capsaicin (CAP) in HaCaT cells and HEK 293T-TRPV1 cells (which were transgenic and overexpressed TRPV1) but had no effect on HEK 293T mock cells (p2 production were higher than those caused by capsazepine, an antagonist of TRPV1, suggesting that GRb1 and PF have great potential in clinical treatment of skin diseases.

Original languageEnglish (US)
Pages (from-to)1279-1283
Number of pages5
JournalInternational Immunopharmacology
Volume10
Issue number10
DOIs
StatePublished - Oct 2010
Externally publishedYes

Fingerprint

Interleukin-8
Keratinocytes
Dinoprostone
Cell Line
HEK293 Cells
Skin Diseases
Capsaicin
Inflammation
ginsenoside Rb1
peoniflorin
vanilloid receptor subtype 1

Keywords

  • Ginsenoside Rb1
  • HaCaT cell
  • IL-8
  • Paeoniflorin
  • PGE
  • TRPV1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

Cite this

Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT. / Huang, Jin; Qiu, Lei; Ding, Li; Wang, Shaozhan; Wang, Jing; Zhu, Quangang; Song, Fengyu; Hu, Jinhong.

In: International Immunopharmacology, Vol. 10, No. 10, 10.2010, p. 1279-1283.

Research output: Contribution to journalArticle

Huang, Jin ; Qiu, Lei ; Ding, Li ; Wang, Shaozhan ; Wang, Jing ; Zhu, Quangang ; Song, Fengyu ; Hu, Jinhong. / Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT. In: International Immunopharmacology. 2010 ; Vol. 10, No. 10. pp. 1279-1283.
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AU - Ding, Li

AU - Wang, Shaozhan

AU - Wang, Jing

AU - Zhu, Quangang

AU - Song, Fengyu

AU - Hu, Jinhong

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