Glandular neoplasms of the urachus: A report of 55 cases emphasizing mucinous cystic tumors with proposed classification

Mahul B. Amin, Steven C. Smith, John Eble, Priya Rao, William W L Choi, Pheroze Tamboli, Robert H. Young

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Published experience remains limited for glandular neoplasms of the urachus, especially mucinous cystic tumors. We reviewed 55 glandular urachal neoplasms to evaluate their clinical features and histopathologic spectrum and to devise a classification system for the mucinous cystic forms. Within the 55 cases studied, we observed 2 groups with differing clinical, gross, and histopathologic features. The first group, invasive, noncystic adenocarcinomas (n=24), had clinicopathologic features in accord with the known spectrum of urachal adenocarcinoma (mean age 50 y, female:male ratio 1.7, with recurrence or death from disease in 9/16 cases over a 45 mo mean follow-up). The second group, mucinous cystic tumors (n=31), morphologically resembled mucinous cystic tumors of the ovary and appeared classifiable by the same approach (mean age 47 y, female:male ratio 1.4) and included mucinous cystadenoma (n=4), mucinous cystic tumor of low malignant potential (n=22, including 2 cases with intraepithelial carcinoma), and mucinous cystadenocarcinoma with microscopic (n=4) or frank invasion (n=1). Follow-up information was available for 13 patients with mucinous cystic tumors (mean 41 mo); we observed no local recurrence or distant metastasis. This experience suggests that there is a distinct group of glandular, cystic tumors of the urachus that is classifiable in a manner similar to ovarian neoplasms and that has a favorable prognosis after complete excision. As with cystic neoplasms of other organs, rigorous sampling is recommended to identify potentially small foci of carcinoma that could be missed by inadequate sampling. Accordingly, classification based on methods other than complete surgical excision may be hazardous.

Original languageEnglish
Pages (from-to)1033-1045
Number of pages13
JournalAmerican Journal of Surgical Pathology
Volume38
Issue number8
DOIs
StatePublished - 2014

Fingerprint

Urachus
Glandular and Epithelial Neoplasms
Neoplasms
Mucinous Cystadenocarcinoma
Mucinous Cystadenoma
Recurrence
Carcinoma in Situ
Ovarian Neoplasms
Ovary
Adenocarcinoma
Neoplasm Metastasis
Carcinoma

Keywords

  • immunohistochemistry
  • mucinous cystadenocarcinoma
  • mucinous cystadenoma
  • mucinous cystic neoplasm
  • mucinous cystic tumor of low malignant potential
  • urachal adenocarcinoma
  • urachus
  • urinary bladder

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Glandular neoplasms of the urachus : A report of 55 cases emphasizing mucinous cystic tumors with proposed classification. / Amin, Mahul B.; Smith, Steven C.; Eble, John; Rao, Priya; Choi, William W L; Tamboli, Pheroze; Young, Robert H.

In: American Journal of Surgical Pathology, Vol. 38, No. 8, 2014, p. 1033-1045.

Research output: Contribution to journalArticle

Amin, Mahul B. ; Smith, Steven C. ; Eble, John ; Rao, Priya ; Choi, William W L ; Tamboli, Pheroze ; Young, Robert H. / Glandular neoplasms of the urachus : A report of 55 cases emphasizing mucinous cystic tumors with proposed classification. In: American Journal of Surgical Pathology. 2014 ; Vol. 38, No. 8. pp. 1033-1045.
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