Glassy cell carcinoma of the uterine cervix. A light and electron microscopic study of five cases

Thomas M. Ulbright, Deborah J. Gersell

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Five cases of glassy cell carcinoma of the uterine cervix were examined by light and electron microscopy. Light microscopic features included areas of large cells with ground glass and granular cytoplasm, distinct borders, prominent stromal inflammation, and lack of apparent squamous or glandular differentiation. Two neoplasms were associated with separate foci of squamous cell carcinoma in situ and one with endocervical adenocarcinoma. Electron microscopy showed a predominant cell type with cytoplasmic filaments, dilated rough endoplasmic reticulum, Golgi complexes, and large nuclei with complex nucleoli. In some cells there were tonofibrils and well developed desmosomes. The neoplasm of one patient showed poorly developed intracellular lumina. These observations were interpreted to indicate that glassy cell carcinoma is associated with and demonstrates both glandular and squamous differentiation. It is, therefore, properly classified as a type of poorly differentiated adenosquamous carcinoma, which likely develops from the subcylindric reserve cell. The results of this experience reaffirms its poor prognosis.

Original languageEnglish (US)
Pages (from-to)2255-2263
Number of pages9
JournalCancer
Volume51
Issue number12
DOIs
StatePublished - Jun 15 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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