Glaucoma filtration surgery and retinal oxygen saturation

Sveinn Hakon Hardarson, Maria Soffia Gottfredsdottir, Gisli Hreinn Halldorsson, Robert Arnar Karlsson, Jon Atli Benediktsson, Thor Eysteinsson, James M. Beach, Alon Harris, Einar Stefansson

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

PURPOSE. Glaucoma may involve disturbances in retinal oxygenation and blood flow. The purpose of this study was to measure the effect of glaucoma filtration surgery on retinal vessel oxygen saturation. METHODS. A noninvasive spectrophotometric retinal oximeter was used to measure hemoglobin oxygen saturation in retinal arterioles and venules before and after glaucoma filtration surgery. Twenty-five consecutive patients were recruited, and 19 had adequate image quality. Fourteen underwent trabeculectomy and five glaucoma tube surgery. Twelve had primary open-angle glaucoma and seven had exfoliative glaucoma. IOP decreased from 23 ± 7 to 10 ± 4 mm Hg (mean ± SD, P = 0.0001). RESULTS. Oxygen saturation increased in retinal arterioles from 97% ± 4% to 99% ± 6% (n = 19; P = 0.046) after surgery and was unchanged in venules (63% ± 5% before surgery and 64% ± 6% after, P = 0.76). There were no significant changes in saturation in the fellow eyes (P > 0.60). The arteriovenous difference was 34% before and 36% after surgery (P = 0.35). CONCLUSIONS. Glaucoma filtration surgery had almost no effect on retinal vessel oxygen saturation.

Original languageEnglish (US)
Pages (from-to)5247-5250
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume50
Issue number11
DOIs
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Glaucoma filtration surgery and retinal oxygen saturation'. Together they form a unique fingerprint.

Cite this