Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change

David W. Evans, Alon Harris, Melanie Garrett, Hak Sung Chung, Larry Kagemann

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Background/aims - Autoregulation of blood flow during posture change is important to ensure consistent organ circulation. The purpose of this study was to compare the change in retrobulbar ocular blood flow in glaucoma patients with normal subjects during supine and upright posture. Methods - 20 open angle glaucoma patients and 20 normal subjects, similar in age and sex distribution, were evaluated. Blood pressure, intraocular pressure, and retrobulbar blood velocity were tested after 30 minutes of sitting and again after 30 minutes of lying. Retrobulbar haemodynamic measures of peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI) were obtained in the ophthalmic and central retinal arteries using colour Doppler imaging (CDI). Results - When changing from the upright to supine posture, normal subjects demonstrated a significant increase in OA EDV (p = 0.016) and significant decrease in OA RI (p = 0.0006) and CRA RI (p = 0.016). Glaucoma patients demonstrated similar changes in OA measures of EDV (p = 0.02) and RI (p = 0.04), but no change in CRA measures. Conclusion - Glaucoma patients exhibit faulty autoregulation of central retinal artery blood flow during posture change.

Original languageEnglish
Pages (from-to)809-813
Number of pages5
JournalBritish Journal of Ophthalmology
Volume83
Issue number7
StatePublished - 1999

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Posture
Glaucoma
Homeostasis
Retinal Artery
Sex Distribution
Open Angle Glaucoma
Age Distribution
Intraocular Pressure
Color
Hemodynamics
Blood Pressure

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change. / Evans, David W.; Harris, Alon; Garrett, Melanie; Chung, Hak Sung; Kagemann, Larry.

In: British Journal of Ophthalmology, Vol. 83, No. 7, 1999, p. 809-813.

Research output: Contribution to journalArticle

Evans, David W. ; Harris, Alon ; Garrett, Melanie ; Chung, Hak Sung ; Kagemann, Larry. / Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change. In: British Journal of Ophthalmology. 1999 ; Vol. 83, No. 7. pp. 809-813.
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