Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change

David W. Evans, Alon Harris, Melanie Garrett, Hak Sung Chung, Larry Kagemann

Research output: Contribution to journalArticle

104 Scopus citations


Background/aims - Autoregulation of blood flow during posture change is important to ensure consistent organ circulation. The purpose of this study was to compare the change in retrobulbar ocular blood flow in glaucoma patients with normal subjects during supine and upright posture. Methods - 20 open angle glaucoma patients and 20 normal subjects, similar in age and sex distribution, were evaluated. Blood pressure, intraocular pressure, and retrobulbar blood velocity were tested after 30 minutes of sitting and again after 30 minutes of lying. Retrobulbar haemodynamic measures of peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI) were obtained in the ophthalmic and central retinal arteries using colour Doppler imaging (CDI). Results - When changing from the upright to supine posture, normal subjects demonstrated a significant increase in OA EDV (p = 0.016) and significant decrease in OA RI (p = 0.0006) and CRA RI (p = 0.016). Glaucoma patients demonstrated similar changes in OA measures of EDV (p = 0.02) and RI (p = 0.04), but no change in CRA measures. Conclusion - Glaucoma patients exhibit faulty autoregulation of central retinal artery blood flow during posture change.

Original languageEnglish (US)
Pages (from-to)809-813
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number7
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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