Gleason score 7 prostate cancer

A heterogeneous entity? Correlation with pathologic parameters and disease-free survival

Wael A. Sakr, Marcos V. Tefilli, David Grignon, Mousumi Banerjee, Jyotirmoy Dey, Edward L. Gheiler, Rabi Tiguert, Isaac J. Powell, David P. Wood

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Objectives. Gleason score 7, in different proportions of grades 3 and 4, is the score most frequently assigned to prostate cancer in our radical prostatectomy specimens (RPSs). We correlated the major grade component of score 7 tumors with clinicopathologic parameters and disease-free survival.Methods. All Gleason score 7 RPSs were classified as having a major grade of 3 or 4 carcinoma. The two groups were compared according to patient age, race, serum prostate-specific antigen (PSA) level, clinical and pathologic stage, tumor volume, and biochemical recurrence.Results. Of the 534 patients analyzed, 356 and 178 had major grade 3 or 4 tumors, respectively. Compared with patients with 3+4 tumors, those with 4+3 had significantly more advanced clinical and pathologic stages, larger tumor volume, higher preoperative PSA levels, and older age and a higher proportion were African American (P

Original languageEnglish (US)
Pages (from-to)730-734
Number of pages5
JournalUrology
Volume56
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

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Neoplasm Grading
Disease-Free Survival
Prostatic Neoplasms
Prostate-Specific Antigen
Prostatectomy
Tumor Burden
Neoplasms
African Americans
Carcinoma
Recurrence
Serum

ASJC Scopus subject areas

  • Urology

Cite this

Gleason score 7 prostate cancer : A heterogeneous entity? Correlation with pathologic parameters and disease-free survival. / Sakr, Wael A.; Tefilli, Marcos V.; Grignon, David; Banerjee, Mousumi; Dey, Jyotirmoy; Gheiler, Edward L.; Tiguert, Rabi; Powell, Isaac J.; Wood, David P.

In: Urology, Vol. 56, No. 5, 2000, p. 730-734.

Research output: Contribution to journalArticle

Sakr, WA, Tefilli, MV, Grignon, D, Banerjee, M, Dey, J, Gheiler, EL, Tiguert, R, Powell, IJ & Wood, DP 2000, 'Gleason score 7 prostate cancer: A heterogeneous entity? Correlation with pathologic parameters and disease-free survival', Urology, vol. 56, no. 5, pp. 730-734. https://doi.org/10.1016/S0090-4295(00)00791-3
Sakr, Wael A. ; Tefilli, Marcos V. ; Grignon, David ; Banerjee, Mousumi ; Dey, Jyotirmoy ; Gheiler, Edward L. ; Tiguert, Rabi ; Powell, Isaac J. ; Wood, David P. / Gleason score 7 prostate cancer : A heterogeneous entity? Correlation with pathologic parameters and disease-free survival. In: Urology. 2000 ; Vol. 56, No. 5. pp. 730-734.
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AU - Sakr, Wael A.

AU - Tefilli, Marcos V.

AU - Grignon, David

AU - Banerjee, Mousumi

AU - Dey, Jyotirmoy

AU - Gheiler, Edward L.

AU - Tiguert, Rabi

AU - Powell, Isaac J.

AU - Wood, David P.

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AB - Objectives. Gleason score 7, in different proportions of grades 3 and 4, is the score most frequently assigned to prostate cancer in our radical prostatectomy specimens (RPSs). We correlated the major grade component of score 7 tumors with clinicopathologic parameters and disease-free survival.Methods. All Gleason score 7 RPSs were classified as having a major grade of 3 or 4 carcinoma. The two groups were compared according to patient age, race, serum prostate-specific antigen (PSA) level, clinical and pathologic stage, tumor volume, and biochemical recurrence.Results. Of the 534 patients analyzed, 356 and 178 had major grade 3 or 4 tumors, respectively. Compared with patients with 3+4 tumors, those with 4+3 had significantly more advanced clinical and pathologic stages, larger tumor volume, higher preoperative PSA levels, and older age and a higher proportion were African American (P

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