Global variations in mortality in adults after initiating antiretroviral treatment: An updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration

Leigh F. Johnson, Nanina Anderegg, Elizabeth Zaniewski, Jeffrey W. Eaton, Peter F. Rebeiro, Gabriela Carriquiry, Denis Nash, Marcel Yotebieng, Didier K. Ekouevi, Charles B. Holmes, Jun Y. Choi, Awachana Jiamsakul, Giorgos Bakoyannis, Keri N. Althoff, Annette H. Sohn, Constantin Yiannoutsos, Matthias Egger

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2 Citations (Scopus)

Abstract

Background:UNAIDS models use data from the International epidemiology Databases to Evaluate AIDS (IeDEA) collaboration in setting assumptions about mortality rates after antiretroviral treatment (ART) initiation. This study aims to update these assumptions with new data, to quantify the extent of regional variation in ART mortality and to assess trends in ART mortality.Methods:Adult ART patients from Africa, Asia and the Americas were included if they had a known date of ART initiation during 2001-2017 and a baseline CD4+ cell count. In cohorts that relied only on passive follow-up (no patient tracing or linkage to vital registration systems), mortality outcomes were imputed in patients lost to follow-up based on a meta-analysis of tracing study data. Poisson regression models were fitted to the mortality data.Results:464 048 ART patients were included. In multivariable analysis, mortality rates were lowest in Asia and highest in Africa, with no significant differences between African regions. Adjusted mortality rates varied significantly between programmes within regions. Mortality rates in the first 12 months after ART initiation were significantly higher during 2001-2006 than during 2010-2014, although the difference was more substantial in Asia and the Americas [adjusted incidence rate ratio (aIRR) 1.43, 95% CI: 1.22-1.66] than in Africa (aIRR 1.07, 95% CI: 1.04-1.11).Conclusion:There is substantial variation in ART mortality between and within regions, even after controlling for differences in mortality by age, sex, baseline CD4 category and calendar period. ART mortality rates have declined substantially over time, although declines have been slower in Africa.

Original languageEnglish (US)
Pages (from-to)S283-S294
JournalAIDS
Volume33
DOIs
StatePublished - Dec 15 2019

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Acquired Immunodeficiency Syndrome
Epidemiology
Databases
Mortality
Therapeutics
Lost to Follow-Up
Incidence
CD4 Lymphocyte Count
Meta-Analysis

Keywords

  • AIDS
  • highly active antiretroviral therapy
  • HIV
  • mortality

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Global variations in mortality in adults after initiating antiretroviral treatment : An updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration. / Johnson, Leigh F.; Anderegg, Nanina; Zaniewski, Elizabeth; Eaton, Jeffrey W.; Rebeiro, Peter F.; Carriquiry, Gabriela; Nash, Denis; Yotebieng, Marcel; Ekouevi, Didier K.; Holmes, Charles B.; Choi, Jun Y.; Jiamsakul, Awachana; Bakoyannis, Giorgos; Althoff, Keri N.; Sohn, Annette H.; Yiannoutsos, Constantin; Egger, Matthias.

In: AIDS, Vol. 33, 15.12.2019, p. S283-S294.

Research output: Contribution to journalArticle

Johnson, LF, Anderegg, N, Zaniewski, E, Eaton, JW, Rebeiro, PF, Carriquiry, G, Nash, D, Yotebieng, M, Ekouevi, DK, Holmes, CB, Choi, JY, Jiamsakul, A, Bakoyannis, G, Althoff, KN, Sohn, AH, Yiannoutsos, C & Egger, M 2019, 'Global variations in mortality in adults after initiating antiretroviral treatment: An updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration', AIDS, vol. 33, pp. S283-S294. https://doi.org/10.1097/QAD.0000000000002358
Johnson, Leigh F. ; Anderegg, Nanina ; Zaniewski, Elizabeth ; Eaton, Jeffrey W. ; Rebeiro, Peter F. ; Carriquiry, Gabriela ; Nash, Denis ; Yotebieng, Marcel ; Ekouevi, Didier K. ; Holmes, Charles B. ; Choi, Jun Y. ; Jiamsakul, Awachana ; Bakoyannis, Giorgos ; Althoff, Keri N. ; Sohn, Annette H. ; Yiannoutsos, Constantin ; Egger, Matthias. / Global variations in mortality in adults after initiating antiretroviral treatment : An updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration. In: AIDS. 2019 ; Vol. 33. pp. S283-S294.
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abstract = "Background:UNAIDS models use data from the International epidemiology Databases to Evaluate AIDS (IeDEA) collaboration in setting assumptions about mortality rates after antiretroviral treatment (ART) initiation. This study aims to update these assumptions with new data, to quantify the extent of regional variation in ART mortality and to assess trends in ART mortality.Methods:Adult ART patients from Africa, Asia and the Americas were included if they had a known date of ART initiation during 2001-2017 and a baseline CD4+ cell count. In cohorts that relied only on passive follow-up (no patient tracing or linkage to vital registration systems), mortality outcomes were imputed in patients lost to follow-up based on a meta-analysis of tracing study data. Poisson regression models were fitted to the mortality data.Results:464 048 ART patients were included. In multivariable analysis, mortality rates were lowest in Asia and highest in Africa, with no significant differences between African regions. Adjusted mortality rates varied significantly between programmes within regions. Mortality rates in the first 12 months after ART initiation were significantly higher during 2001-2006 than during 2010-2014, although the difference was more substantial in Asia and the Americas [adjusted incidence rate ratio (aIRR) 1.43, 95{\%} CI: 1.22-1.66] than in Africa (aIRR 1.07, 95{\%} CI: 1.04-1.11).Conclusion:There is substantial variation in ART mortality between and within regions, even after controlling for differences in mortality by age, sex, baseline CD4 category and calendar period. ART mortality rates have declined substantially over time, although declines have been slower in Africa.",
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AU - Zaniewski, Elizabeth

AU - Eaton, Jeffrey W.

AU - Rebeiro, Peter F.

AU - Carriquiry, Gabriela

AU - Nash, Denis

AU - Yotebieng, Marcel

AU - Ekouevi, Didier K.

AU - Holmes, Charles B.

AU - Choi, Jun Y.

AU - Jiamsakul, Awachana

AU - Bakoyannis, Giorgos

AU - Althoff, Keri N.

AU - Sohn, Annette H.

AU - Yiannoutsos, Constantin

AU - Egger, Matthias

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N2 - Background:UNAIDS models use data from the International epidemiology Databases to Evaluate AIDS (IeDEA) collaboration in setting assumptions about mortality rates after antiretroviral treatment (ART) initiation. This study aims to update these assumptions with new data, to quantify the extent of regional variation in ART mortality and to assess trends in ART mortality.Methods:Adult ART patients from Africa, Asia and the Americas were included if they had a known date of ART initiation during 2001-2017 and a baseline CD4+ cell count. In cohorts that relied only on passive follow-up (no patient tracing or linkage to vital registration systems), mortality outcomes were imputed in patients lost to follow-up based on a meta-analysis of tracing study data. Poisson regression models were fitted to the mortality data.Results:464 048 ART patients were included. In multivariable analysis, mortality rates were lowest in Asia and highest in Africa, with no significant differences between African regions. Adjusted mortality rates varied significantly between programmes within regions. Mortality rates in the first 12 months after ART initiation were significantly higher during 2001-2006 than during 2010-2014, although the difference was more substantial in Asia and the Americas [adjusted incidence rate ratio (aIRR) 1.43, 95% CI: 1.22-1.66] than in Africa (aIRR 1.07, 95% CI: 1.04-1.11).Conclusion:There is substantial variation in ART mortality between and within regions, even after controlling for differences in mortality by age, sex, baseline CD4 category and calendar period. ART mortality rates have declined substantially over time, although declines have been slower in Africa.

AB - Background:UNAIDS models use data from the International epidemiology Databases to Evaluate AIDS (IeDEA) collaboration in setting assumptions about mortality rates after antiretroviral treatment (ART) initiation. This study aims to update these assumptions with new data, to quantify the extent of regional variation in ART mortality and to assess trends in ART mortality.Methods:Adult ART patients from Africa, Asia and the Americas were included if they had a known date of ART initiation during 2001-2017 and a baseline CD4+ cell count. In cohorts that relied only on passive follow-up (no patient tracing or linkage to vital registration systems), mortality outcomes were imputed in patients lost to follow-up based on a meta-analysis of tracing study data. Poisson regression models were fitted to the mortality data.Results:464 048 ART patients were included. In multivariable analysis, mortality rates were lowest in Asia and highest in Africa, with no significant differences between African regions. Adjusted mortality rates varied significantly between programmes within regions. Mortality rates in the first 12 months after ART initiation were significantly higher during 2001-2006 than during 2010-2014, although the difference was more substantial in Asia and the Americas [adjusted incidence rate ratio (aIRR) 1.43, 95% CI: 1.22-1.66] than in Africa (aIRR 1.07, 95% CI: 1.04-1.11).Conclusion:There is substantial variation in ART mortality between and within regions, even after controlling for differences in mortality by age, sex, baseline CD4 category and calendar period. ART mortality rates have declined substantially over time, although declines have been slower in Africa.

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KW - highly active antiretroviral therapy

KW - HIV

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