Glomerular filtration barrier in aminoglycoside-induced nephrotoxic acute renal failure

F. C. Luft, Andrew Evan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To elucidate the role of the glomerular filtration barrier in the development of nephrotoxic acute renal failure, we produced acute renal failure in rats with either gentamicin or tobramycin. Both drugs evoked changes in the gomerular capillary endothelium. Gentamicin administration resulted in a dose-related decrease in the diameter, density and area of endothelial fenestrae, which was considerably more pronounced than those observed with tobramycin. Prolonged, high-dose gentamicin administration caused a decrease in creatinine clearance, an increase in plasma renin activity and a corresponding decrease in the area available for filtration. These changes reverted with continued drug administration. These results support the notion that morphological alterations in the filtration barrier are responsible for the decrease in filtration observed in acute renal failure. The changes may be at least in part mediated by the renin-angiotensin system.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalRenal Physiology
Volume3
Issue number1-6
StatePublished - 1980

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Glomerular Filtration Barrier
Aminoglycosides
Gentamicins
Acute Kidney Injury
Tobramycin
Vascular Endothelium
Renin-Angiotensin System
Renin
Pharmaceutical Preparations
Creatinine

ASJC Scopus subject areas

  • Physiology
  • Nephrology

Cite this

Glomerular filtration barrier in aminoglycoside-induced nephrotoxic acute renal failure. / Luft, F. C.; Evan, Andrew.

In: Renal Physiology, Vol. 3, No. 1-6, 1980, p. 265-271.

Research output: Contribution to journalArticle

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