Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease

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9 Citations (Scopus)

Abstract

The central nervous system (CNS) is a large network of intercommunicating cells that function to maintain tissue health and homeostasis. Considerable evidence suggests that glucocorticoids exert both neuroprotective and neurodegenerative effects on the CNS. Glucocorticoids act by binding two related receptors in the cytoplasm, the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). The glucocorticoid receptor complex mediates cellular responses by transactivating target genes and by protein: protein interactions. The paradoxical effects of glucocorticoids on neuronal survival and death have been attributed to the concentration and the ratio of mineralocorticoid to glucocorticoid receptor activation. Glucocorticoid-induced leucine zipper (GILZ) is a recently identified protein transcriptionally upregulated by glucocorticoids. Constitutively, expressed in many tissues including brain, GILZ mediates many of the actions of glucocorticoids. It mimics the anti-inflammatory and anti-proliferative effects of glucocorticoids but exerts differential effects on stem cell differentiation and lineage development. Recent experimental data on the effects of GILZ following induced stress or trauma suggest potential roles in CNS diseases. Here, we provide a short overview of the role of GILZ in CNS health and discuss three potential rationales for the role of GILZ in Alzheimer’s disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalMolecular Neurobiology
DOIs
StateAccepted/In press - Nov 26 2016

Fingerprint

Leucine Zippers
Central Nervous System Diseases
Glucocorticoids
Health
Glucocorticoid Receptors
Central Nervous System
Mineralocorticoid Receptors
Mineralocorticoids
Proteins
Neuroprotective Agents
Cell Lineage
Cell Differentiation
Alzheimer Disease
Cytoplasm
Homeostasis
Anti-Inflammatory Agents
Stem Cells

Keywords

  • Alzheimer’s disease
  • Glucocorticoid-induced leucine zipper
  • Glucocorticoids

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

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title = "Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease",
abstract = "The central nervous system (CNS) is a large network of intercommunicating cells that function to maintain tissue health and homeostasis. Considerable evidence suggests that glucocorticoids exert both neuroprotective and neurodegenerative effects on the CNS. Glucocorticoids act by binding two related receptors in the cytoplasm, the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). The glucocorticoid receptor complex mediates cellular responses by transactivating target genes and by protein: protein interactions. The paradoxical effects of glucocorticoids on neuronal survival and death have been attributed to the concentration and the ratio of mineralocorticoid to glucocorticoid receptor activation. Glucocorticoid-induced leucine zipper (GILZ) is a recently identified protein transcriptionally upregulated by glucocorticoids. Constitutively, expressed in many tissues including brain, GILZ mediates many of the actions of glucocorticoids. It mimics the anti-inflammatory and anti-proliferative effects of glucocorticoids but exerts differential effects on stem cell differentiation and lineage development. Recent experimental data on the effects of GILZ following induced stress or trauma suggest potential roles in CNS diseases. Here, we provide a short overview of the role of GILZ in CNS health and discuss three potential rationales for the role of GILZ in Alzheimer’s disease pathogenesis.",
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