Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome

Frank González, John P. Kirwan, Neal S. Rote, Judi Minium

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Women with polycystic ovary syndrome (PCOS) have chronic lowgrade inflammation that can increase the risk of atherothrombosis. We performed a cross-sectional study to examine the effect of glucose ingestion on markers of atherothrombotic inflammation in mononuclear cells (MNC) of 16 women with PCOS (8 lean, 8 obese) and 16 weight-matched controls. Activator protein-1 (AP-1) activation and the protein content of early growth response-1 (EGR-1), matrix matalloproteinases-2 (MMP2), and tissue factor (TF) were quantified from MNC obtained from blood drawn fasting and 2 h after glucose ingestion. Plasma MMP9 and C-reactive protein (CRP) were measured from fasting blood samples. Truncal fat was determined by DEXA. Lean women with PCOS exhibited greater AP-1 activation and MMP2 protein content after glucose ingestion and higher plasma MMP9 and CRP levels than lean controls. Obese women with PCOS exhibited greater EGR-1 and TF protein content after glucose ingestion, and plasma CRP levels were even higher compared with lean subjects regardless of PCOS status. Truncal fat correlated with MMP9 and CRP levels and glucose-stimulated increases in AP-1 activation and EGR-1 and TF protein content. Testosterone correlated with glucose-stimulated AP-1 activation, and androstenedione correlated with MMP9 and CRP levels and glucose-stimulated AP-1 activation. Thus, both PCOS and obesity contribute to an atherothrombotic state in which excess abdominal adiposity and hyperandrogenism may be specific risk factors for developing atherothrombosis.

Original languageEnglish
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume304
Issue number4
DOIs
StatePublished - Feb 15 2013

Fingerprint

Polycystic Ovary Syndrome
Transcription Factor AP-1
Eating
Inflammation
C-Reactive Protein
Glucose
Thromboplastin
Fasting
Early Growth Response Protein 1
Fats
Hyperandrogenism
Proteins
Androstenedione
Adiposity
Growth
Testosterone
Blood Proteins
Blood Cells
Obesity
Cross-Sectional Studies

Keywords

  • Abdominal adiposity
  • Atherosclerosis
  • Glucose
  • Inflammation
  • Thrombosis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Endocrinology, Diabetes and Metabolism

Cite this

Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome. / González, Frank; Kirwan, John P.; Rote, Neal S.; Minium, Judi.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 304, No. 4, 15.02.2013.

Research output: Contribution to journalArticle

González, Frank ; Kirwan, John P. ; Rote, Neal S. ; Minium, Judi. / Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome. In: American Journal of Physiology - Endocrinology and Metabolism. 2013 ; Vol. 304, No. 4.
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