Glucose level decline precedes dementia in elderly African Americans with diabetes

Hugh C. Hendrie, Mengjie Zheng, Wei Li, Kathleen Lane, Roberta Ambuehl, Christianna Purnell, Frederick W. Unverzagt, Alexia Torke, Ashok Balasubramanyam, Chris M. Callahan, Sujuan Gao

Research output: Contribution to journalArticle

6 Scopus citations


Introduction High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients. Methods A secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis–Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome variables. Results Diabetic participants who developed incident dementia had a significant decrease in serum glucose levels in the years preceding the diagnosis compared to the participants with normal cognition (P = .0002). They also had significantly higher glucose levels up to 9 years before the dementia diagnosis (P = .0367). Discussion High glucose levels followed by a decline occurring years before diagnosis in African American participants with diabetes may represent a powerful presymptomatic metabolic indicator of dementia.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalAlzheimer's and Dementia
Issue number2
StatePublished - Feb 1 2017


  • African Americans
  • Alzheimer disease
  • Dementia
  • Diabetes
  • Early detection
  • Electronic medical records
  • Glucose levels
  • Longitudinal risk factors

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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