Glucose level decline precedes dementia in elderly African Americans with diabetes

Hugh Hendrie, Mengjie Zheng, Wei Li, Kathleen Lane, Roberta Ambuehl, Christianna Purnell, Frederick Unverzagt, Alexia Torke, Ashok Balasubramanyam, Christopher Callahan, Sujuan Gao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction: High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients. Methods: A secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis-Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome variables. Results: Diabetic participants who developed incident dementia had a significant decrease in serum glucose levels in the years preceding the diagnosis compared to the participants with normal cognition (P = .0002). They also had significantly higher glucose levels up to 9 years before the dementia diagnosis (P = .0367). Discussion: High glucose levels followed by a decline occurring years before diagnosis in African American participants with diabetes may represent a powerful presymptomatic metabolic indicator of dementia.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2016

Fingerprint

African Americans
Dementia
Glucose
Electronic Health Records
Cognition
Serum
Blood Glucose

Keywords

  • African Americans
  • Alzheimer disease
  • Dementia
  • Diabetes
  • Early detection
  • Electronic medical records
  • Glucose levels
  • Longitudinal risk factors

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Glucose level decline precedes dementia in elderly African Americans with diabetes. / Hendrie, Hugh; Zheng, Mengjie; Li, Wei; Lane, Kathleen; Ambuehl, Roberta; Purnell, Christianna; Unverzagt, Frederick; Torke, Alexia; Balasubramanyam, Ashok; Callahan, Christopher; Gao, Sujuan.

In: Alzheimer's and Dementia, 2016.

Research output: Contribution to journalArticle

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AU - Zheng, Mengjie

AU - Li, Wei

AU - Lane, Kathleen

AU - Ambuehl, Roberta

AU - Purnell, Christianna

AU - Unverzagt, Frederick

AU - Torke, Alexia

AU - Balasubramanyam, Ashok

AU - Callahan, Christopher

AU - Gao, Sujuan

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N2 - Introduction: High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients. Methods: A secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis-Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome variables. Results: Diabetic participants who developed incident dementia had a significant decrease in serum glucose levels in the years preceding the diagnosis compared to the participants with normal cognition (P = .0002). They also had significantly higher glucose levels up to 9 years before the dementia diagnosis (P = .0367). Discussion: High glucose levels followed by a decline occurring years before diagnosis in African American participants with diabetes may represent a powerful presymptomatic metabolic indicator of dementia.

AB - Introduction: High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients. Methods: A secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis-Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome variables. Results: Diabetic participants who developed incident dementia had a significant decrease in serum glucose levels in the years preceding the diagnosis compared to the participants with normal cognition (P = .0002). They also had significantly higher glucose levels up to 9 years before the dementia diagnosis (P = .0367). Discussion: High glucose levels followed by a decline occurring years before diagnosis in African American participants with diabetes may represent a powerful presymptomatic metabolic indicator of dementia.

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