Abstract
1. Glucose phosphorylation is the first irreversible step of the muscle glucose uptake pathway and is catalysed by a hexokinase isozyme. 2. While glucose transport is the primary barrier to muscle glucose uptake during basal conditions, glucose phosphorylation becomes an important barrier to muscle glucose uptake during stimulated conditions such as hyperinsulinaemia or exercise. 3. High fat feeding markedly impairs insulin- and exercise-stimulated muscle glucose uptake. As hexokinase II overexpression corrects this dietary-induced deficit during exercise, glucose phosphorylation is a site of impairment following high fat feeding. 4. Exercise is an important tool for diagnosing deficits in glucose phosphorylation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 314-318 |
| Number of pages | 5 |
| Journal | Clinical and Experimental Pharmacology and Physiology |
| Volume | 32 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2005 |
| Externally published | Yes |
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Keywords
- 2-deoxyglucose
- Distributed control
- Exercise
- Hexokinase
- Insulin clamp
- Mice
ASJC Scopus subject areas
- Physiology
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Glucose phosphorylation as a barrier to muscle glucose uptake. / Fueger, Patrick T.
In: Clinical and Experimental Pharmacology and Physiology, Vol. 32, No. 4, 04.2005, p. 314-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glucose phosphorylation as a barrier to muscle glucose uptake
AU - Fueger, Patrick T.
PY - 2005/4
Y1 - 2005/4
N2 - 1. Glucose phosphorylation is the first irreversible step of the muscle glucose uptake pathway and is catalysed by a hexokinase isozyme. 2. While glucose transport is the primary barrier to muscle glucose uptake during basal conditions, glucose phosphorylation becomes an important barrier to muscle glucose uptake during stimulated conditions such as hyperinsulinaemia or exercise. 3. High fat feeding markedly impairs insulin- and exercise-stimulated muscle glucose uptake. As hexokinase II overexpression corrects this dietary-induced deficit during exercise, glucose phosphorylation is a site of impairment following high fat feeding. 4. Exercise is an important tool for diagnosing deficits in glucose phosphorylation.
AB - 1. Glucose phosphorylation is the first irreversible step of the muscle glucose uptake pathway and is catalysed by a hexokinase isozyme. 2. While glucose transport is the primary barrier to muscle glucose uptake during basal conditions, glucose phosphorylation becomes an important barrier to muscle glucose uptake during stimulated conditions such as hyperinsulinaemia or exercise. 3. High fat feeding markedly impairs insulin- and exercise-stimulated muscle glucose uptake. As hexokinase II overexpression corrects this dietary-induced deficit during exercise, glucose phosphorylation is a site of impairment following high fat feeding. 4. Exercise is an important tool for diagnosing deficits in glucose phosphorylation.
KW - 2-deoxyglucose
KW - Distributed control
KW - Exercise
KW - Hexokinase
KW - Insulin clamp
KW - Mice
UR - http://www.scopus.com/inward/record.url?scp=17844388305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17844388305&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1681.2005.04190.x
DO - 10.1111/j.1440-1681.2005.04190.x
M3 - Article
C2 - 15810998
AN - SCOPUS:17844388305
VL - 32
SP - 314
EP - 318
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
SN - 0305-1870
IS - 4
ER -