Glucose phosphorylation as a barrier to muscle glucose uptake

Patrick T. Fueger

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

1. Glucose phosphorylation is the first irreversible step of the muscle glucose uptake pathway and is catalysed by a hexokinase isozyme. 2. While glucose transport is the primary barrier to muscle glucose uptake during basal conditions, glucose phosphorylation becomes an important barrier to muscle glucose uptake during stimulated conditions such as hyperinsulinaemia or exercise. 3. High fat feeding markedly impairs insulin- and exercise-stimulated muscle glucose uptake. As hexokinase II overexpression corrects this dietary-induced deficit during exercise, glucose phosphorylation is a site of impairment following high fat feeding. 4. Exercise is an important tool for diagnosing deficits in glucose phosphorylation.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume32
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Phosphorylation
Glucose
Muscles
Hexokinase
Fats
Hyperinsulinism
Isoenzymes
Insulin

Keywords

  • 2-deoxyglucose
  • Distributed control
  • Exercise
  • Hexokinase
  • Insulin clamp
  • Mice

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Glucose phosphorylation as a barrier to muscle glucose uptake. / Fueger, Patrick T.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 32, No. 4, 04.2005, p. 314-318.

Research output: Contribution to journalArticle

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