GLUT4's itinerary in health & disease

Alicia M. McCarthy, Jeffrey Elmendorf

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Following the discovery of insulin 85 yr ago and the realization thereafter that in some individuals, tissues lose their responsiveness to this hormone, an enormous world-wide effort began to dissect the cellular mechanisms of insulin action and define abnormalities in the insulin-resistant state. A clear goal through the years has been to unravel the insulin signal transduction network regulating glucose transport. This line of investigation has provided tremendous insight into the physiology and pathophysiology surrounding the cellular processes controlled by insulin. Between the plasma membrane insulin receptor and the intracellularly sequestered insulin-responsive glucose transporter GLUT4, many events participate in the transduction of the insulin signal. In this review, we detail our current state of knowledge on the intricate insulin signaling network responsible for glucose transport in peripheral adipose and skeletal muscle tissues. In particular, we identify signaling connections spanning the insulin receptor and GLUT4. In addition, we discuss cytoskeletal mechanics and membrane docking and fusion mechanisms pertinently involved in the cellular redistribution of GLUT4 to the plasma membrane. On the whole, this review highlights the considerable progress in our understanding of insulin signaling in health and disease as we rapidly approach the centennial anniversary of insulin's discovery.

Original languageEnglish
Pages (from-to)373-388
Number of pages16
JournalIndian Journal of Medical Research
Volume125
Issue number3
StatePublished - Mar 2007

Fingerprint

Health
Insulin
Insulin Receptor
Cell membranes
Signal Transduction
Glucose Transporter Type 4
Cell Membrane
Tissue
Glucose
Signal transduction
Membrane Fusion
Physiology
Anniversaries and Special Events
Mechanics
Muscle
Skeletal Muscle
Fusion reactions
Hormones
Membranes
Muscles

Keywords

  • Glucose transporter 4 (GLUT4)
  • Insulin
  • Insulin resistance
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

GLUT4's itinerary in health & disease. / McCarthy, Alicia M.; Elmendorf, Jeffrey.

In: Indian Journal of Medical Research, Vol. 125, No. 3, 03.2007, p. 373-388.

Research output: Contribution to journalArticle

McCarthy, Alicia M. ; Elmendorf, Jeffrey. / GLUT4's itinerary in health & disease. In: Indian Journal of Medical Research. 2007 ; Vol. 125, No. 3. pp. 373-388.
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