Glutathione S-transferase and multidrug-resistant phenotype in transitional cell carcinoma of the bladder

A. Akdas, L. N. Turkeri, S. Kullu, T. Tarcan, W. Sakr, David Grignon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To asses the role of expression of resistance phenotypes in treatment failure in patients with invasive transitional cell carcinoma of the urinary bladder, since P-glycoprotein and glutathione S-transferase pi (GST) expression are implicated in resistance to various chemotherapy agents in different tumors. Methods: Tumor samples from P-glycoprotein and GST-pi were analyzed by immunohistochemistry. Results: P-glycoprotein and GST-pi were found in 35.7 and 42.9% of the samples, respectively. In 21.4% of the samples there was simultaneous expression of both proteins. No significant impact on prediction of tumor behavior was evident on statistical analysis by any one of the protein expressions. Conclusion: Drug resistance in transitional cell carcinoma may be through different mechanisms. Although the small sample size of this study precludes firm conclusions, the assessment of P-glycoprotein or GST-pi expression appears to be of little value as a predictor of response to chemotherapy in this group of tumors.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalEuropean Urology
Volume29
Issue number4
StatePublished - 1996
Externally publishedYes

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Glutathione S-Transferase pi
Transitional Cell Carcinoma
P-Glycoprotein
Glutathione Transferase
Urinary Bladder
Phenotype
Neoplasms
Drug Therapy
Equidae
Treatment Failure
Drug Resistance
Sample Size
Proteins
Immunohistochemistry

Keywords

  • Bladder neoplasm
  • Drug resistance
  • Immunohistochemistry

ASJC Scopus subject areas

  • Urology

Cite this

Glutathione S-transferase and multidrug-resistant phenotype in transitional cell carcinoma of the bladder. / Akdas, A.; Turkeri, L. N.; Kullu, S.; Tarcan, T.; Sakr, W.; Grignon, David.

In: European Urology, Vol. 29, No. 4, 1996, p. 483-486.

Research output: Contribution to journalArticle

Akdas, A, Turkeri, LN, Kullu, S, Tarcan, T, Sakr, W & Grignon, D 1996, 'Glutathione S-transferase and multidrug-resistant phenotype in transitional cell carcinoma of the bladder', European Urology, vol. 29, no. 4, pp. 483-486.
Akdas, A. ; Turkeri, L. N. ; Kullu, S. ; Tarcan, T. ; Sakr, W. ; Grignon, David. / Glutathione S-transferase and multidrug-resistant phenotype in transitional cell carcinoma of the bladder. In: European Urology. 1996 ; Vol. 29, No. 4. pp. 483-486.
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AU - Sakr, W.

AU - Grignon, David

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