Glutathione S-transferase and multidrug-resistant phenotype in transitional cell carcinoma of the bladder

A. Akdas, L. N. Turkeri, S. Kullu, T. Tarcan, W. Sakr, D. J. Grignon

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: To asses the role of expression of resistance phenotypes in treatment failure in patients with invasive transitional cell carcinoma of the urinary bladder, since P-glycoprotein and glutathione S-transferase pi (GST) expression are implicated in resistance to various chemotherapy agents in different tumors. Methods: Tumor samples from P-glycoprotein and GST-pi were analyzed by immunohistochemistry. Results: P-glycoprotein and GST-pi were found in 35.7 and 42.9% of the samples, respectively. In 21.4% of the samples there was simultaneous expression of both proteins. No significant impact on prediction of tumor behavior was evident on statistical analysis by any one of the protein expressions. Conclusion: Drug resistance in transitional cell carcinoma may be through different mechanisms. Although the small sample size of this study precludes firm conclusions, the assessment of P-glycoprotein or GST-pi expression appears to be of little value as a predictor of response to chemotherapy in this group of tumors.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalEuropean urology
Volume29
Issue number4
DOIs
StatePublished - Jan 1 1996

Keywords

  • Bladder neoplasm
  • Drug resistance
  • Immunohistochemistry

ASJC Scopus subject areas

  • Urology

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