Glutathione S-transferase expression in renal cell carcinoma

a new marker of differentiation.

David Grignon, M. Abdel-Malak, W. C. Mertens, W. A. Sakr, R. R. Shepherd

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Expression of two GST isoenzymes (alpha and pi) was assessed immunohistochemically in 46 cases of renal cell carcinoma (RCC) for which clinical follow-up was available. In the normal kidney GST alpha stained most intensely in the proximal convoluted tubules and GST pi in distal tubules/collecting ducts. All 46 tumors studied stained positively for GST alpha with most demonstrating strong cytoplasmic and nuclear reactivity. GST pi immunostaining was positive in 35/46 cases (76%). Five-year survival for patients with GST pi positive tumors was 88% versus 50% for those with GST pi negative tumors (P <0.008). Loss of GST mRNA has been reported in RCC and it has been suggested that this may represent a dedifferentiation program in RCC. These data support this hypothesis and further indicate a potential value for GST pi as a prognostic indicator in RCC.

Original languageEnglish (US)
Pages (from-to)186-189
Number of pages4
JournalModern Pathology
Volume7
Issue number2
StatePublished - Feb 1994
Externally publishedYes

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Differentiation Antigens
Glutathione Transferase
Renal Cell Carcinoma
Neoplasms
Isoenzymes
Kidney
Messenger RNA
Survival
glutathione S-transferase alpha

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Grignon, D., Abdel-Malak, M., Mertens, W. C., Sakr, W. A., & Shepherd, R. R. (1994). Glutathione S-transferase expression in renal cell carcinoma: a new marker of differentiation. Modern Pathology, 7(2), 186-189.

Glutathione S-transferase expression in renal cell carcinoma : a new marker of differentiation. / Grignon, David; Abdel-Malak, M.; Mertens, W. C.; Sakr, W. A.; Shepherd, R. R.

In: Modern Pathology, Vol. 7, No. 2, 02.1994, p. 186-189.

Research output: Contribution to journalArticle

Grignon, D, Abdel-Malak, M, Mertens, WC, Sakr, WA & Shepherd, RR 1994, 'Glutathione S-transferase expression in renal cell carcinoma: a new marker of differentiation.', Modern Pathology, vol. 7, no. 2, pp. 186-189.
Grignon, David ; Abdel-Malak, M. ; Mertens, W. C. ; Sakr, W. A. ; Shepherd, R. R. / Glutathione S-transferase expression in renal cell carcinoma : a new marker of differentiation. In: Modern Pathology. 1994 ; Vol. 7, No. 2. pp. 186-189.
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