Glutathione S-transferase expression in renal cell carcinoma: a new marker of differentiation.

D. J. Grignon, M. Abdel-Malak, W. C. Mertens, W. A. Sakr, R. R. Shepherd

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Expression of two GST isoenzymes (alpha and pi) was assessed immunohistochemically in 46 cases of renal cell carcinoma (RCC) for which clinical follow-up was available. In the normal kidney GST alpha stained most intensely in the proximal convoluted tubules and GST pi in distal tubules/collecting ducts. All 46 tumors studied stained positively for GST alpha with most demonstrating strong cytoplasmic and nuclear reactivity. GST pi immunostaining was positive in 35/46 cases (76%). Five-year survival for patients with GST pi positive tumors was 88% versus 50% for those with GST pi negative tumors (P < 0.008). Loss of GST mRNA has been reported in RCC and it has been suggested that this may represent a dedifferentiation program in RCC. These data support this hypothesis and further indicate a potential value for GST pi as a prognostic indicator in RCC.

Original languageEnglish (US)
Pages (from-to)186-189
Number of pages4
JournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Volume7
Issue number2
StatePublished - Feb 1994

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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