Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma

Valle Nazar-Stewart, Thomas L. Vaughan, Richard D. Burt, Chu Chen, Marianne Berwick, G. Marie Swanson

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Genetic polymorphisms for enzymes that metabolize tobacco smoke have been reported to determine susceptibility to several smoking-related cancers, including cancers of the lung, bladder, and head and neck. Glutathione S- transferase M1 (GSTM1) detoxifies benzo(a)pyrene and other carcinogens in tobacco smoke. Approximately 50% of Caucasians lack the GSTM1 gene. Because the most common type of nasopharyngeal cancer (NPC), squamous cell carcinoma, is related to smoking, we sought to determine whether GSTM1 is associated with risk for NPC. Cases (n = 83) were from a population-based study conducted from 1987 to 1993 at five cancer registries in the United StateS. Random-digit dialing controls (n = 114) were matched to the cases for age, sex, and registry. Subjects participated in a phone interview and blood draw. Absence of GSTM1 was associated with increased risk for NPC (odds ratio = 1.9, 95% confidence interval = 1.0-3.3 for all cases; and odds ratio = 1.7, 95% confidence interval = 0.8-3.5 for squamous cell cases). This relationship was not modified by smoking history, but stronger relationships between glutathione S-transferase and NPC were suggested among subjects who used alcohol more frequently than others, older subjects (50 or more years of age), and women relative to men. These data indicate that absence of GSTM1 moderately increases risk for NPC and add to growing evidence that GSTM1 is a determinant of risk for several smoking-related cancers.

Original languageEnglish (US)
Pages (from-to)547-551
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume8
Issue number6
StatePublished - Jun 1999
Externally publishedYes

Fingerprint

Nasopharyngeal Neoplasms
Smoking
Smoke
Tobacco
Registries
Odds Ratio
Confidence Intervals
Neoplasms
Benzo(a)pyrene
Genetic Polymorphisms
Head and Neck Neoplasms
Glutathione Transferase
Urinary Bladder Neoplasms
Carcinogens
Nasopharyngeal carcinoma
glutathione S-transferase M1
Squamous Cell Carcinoma
Lung Neoplasms
Neck
History

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Nazar-Stewart, V., Vaughan, T. L., Burt, R. D., Chen, C., Berwick, M., & Swanson, G. M. (1999). Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma. Cancer Epidemiology Biomarkers and Prevention, 8(6), 547-551.

Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma. / Nazar-Stewart, Valle; Vaughan, Thomas L.; Burt, Richard D.; Chen, Chu; Berwick, Marianne; Swanson, G. Marie.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 8, No. 6, 06.1999, p. 547-551.

Research output: Contribution to journalArticle

Nazar-Stewart, V, Vaughan, TL, Burt, RD, Chen, C, Berwick, M & Swanson, GM 1999, 'Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma', Cancer Epidemiology Biomarkers and Prevention, vol. 8, no. 6, pp. 547-551.
Nazar-Stewart V, Vaughan TL, Burt RD, Chen C, Berwick M, Swanson GM. Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma. Cancer Epidemiology Biomarkers and Prevention. 1999 Jun;8(6):547-551.
Nazar-Stewart, Valle ; Vaughan, Thomas L. ; Burt, Richard D. ; Chen, Chu ; Berwick, Marianne ; Swanson, G. Marie. / Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma. In: Cancer Epidemiology Biomarkers and Prevention. 1999 ; Vol. 8, No. 6. pp. 547-551.
@article{279b778d42644237be5e0f513292c07a,
title = "Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma",
abstract = "Genetic polymorphisms for enzymes that metabolize tobacco smoke have been reported to determine susceptibility to several smoking-related cancers, including cancers of the lung, bladder, and head and neck. Glutathione S- transferase M1 (GSTM1) detoxifies benzo(a)pyrene and other carcinogens in tobacco smoke. Approximately 50{\%} of Caucasians lack the GSTM1 gene. Because the most common type of nasopharyngeal cancer (NPC), squamous cell carcinoma, is related to smoking, we sought to determine whether GSTM1 is associated with risk for NPC. Cases (n = 83) were from a population-based study conducted from 1987 to 1993 at five cancer registries in the United StateS. Random-digit dialing controls (n = 114) were matched to the cases for age, sex, and registry. Subjects participated in a phone interview and blood draw. Absence of GSTM1 was associated with increased risk for NPC (odds ratio = 1.9, 95{\%} confidence interval = 1.0-3.3 for all cases; and odds ratio = 1.7, 95{\%} confidence interval = 0.8-3.5 for squamous cell cases). This relationship was not modified by smoking history, but stronger relationships between glutathione S-transferase and NPC were suggested among subjects who used alcohol more frequently than others, older subjects (50 or more years of age), and women relative to men. These data indicate that absence of GSTM1 moderately increases risk for NPC and add to growing evidence that GSTM1 is a determinant of risk for several smoking-related cancers.",
author = "Valle Nazar-Stewart and Vaughan, {Thomas L.} and Burt, {Richard D.} and Chu Chen and Marianne Berwick and Swanson, {G. Marie}",
year = "1999",
month = "6",
language = "English (US)",
volume = "8",
pages = "547--551",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "6",

}

TY - JOUR

T1 - Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma

AU - Nazar-Stewart, Valle

AU - Vaughan, Thomas L.

AU - Burt, Richard D.

AU - Chen, Chu

AU - Berwick, Marianne

AU - Swanson, G. Marie

PY - 1999/6

Y1 - 1999/6

N2 - Genetic polymorphisms for enzymes that metabolize tobacco smoke have been reported to determine susceptibility to several smoking-related cancers, including cancers of the lung, bladder, and head and neck. Glutathione S- transferase M1 (GSTM1) detoxifies benzo(a)pyrene and other carcinogens in tobacco smoke. Approximately 50% of Caucasians lack the GSTM1 gene. Because the most common type of nasopharyngeal cancer (NPC), squamous cell carcinoma, is related to smoking, we sought to determine whether GSTM1 is associated with risk for NPC. Cases (n = 83) were from a population-based study conducted from 1987 to 1993 at five cancer registries in the United StateS. Random-digit dialing controls (n = 114) were matched to the cases for age, sex, and registry. Subjects participated in a phone interview and blood draw. Absence of GSTM1 was associated with increased risk for NPC (odds ratio = 1.9, 95% confidence interval = 1.0-3.3 for all cases; and odds ratio = 1.7, 95% confidence interval = 0.8-3.5 for squamous cell cases). This relationship was not modified by smoking history, but stronger relationships between glutathione S-transferase and NPC were suggested among subjects who used alcohol more frequently than others, older subjects (50 or more years of age), and women relative to men. These data indicate that absence of GSTM1 moderately increases risk for NPC and add to growing evidence that GSTM1 is a determinant of risk for several smoking-related cancers.

AB - Genetic polymorphisms for enzymes that metabolize tobacco smoke have been reported to determine susceptibility to several smoking-related cancers, including cancers of the lung, bladder, and head and neck. Glutathione S- transferase M1 (GSTM1) detoxifies benzo(a)pyrene and other carcinogens in tobacco smoke. Approximately 50% of Caucasians lack the GSTM1 gene. Because the most common type of nasopharyngeal cancer (NPC), squamous cell carcinoma, is related to smoking, we sought to determine whether GSTM1 is associated with risk for NPC. Cases (n = 83) were from a population-based study conducted from 1987 to 1993 at five cancer registries in the United StateS. Random-digit dialing controls (n = 114) were matched to the cases for age, sex, and registry. Subjects participated in a phone interview and blood draw. Absence of GSTM1 was associated with increased risk for NPC (odds ratio = 1.9, 95% confidence interval = 1.0-3.3 for all cases; and odds ratio = 1.7, 95% confidence interval = 0.8-3.5 for squamous cell cases). This relationship was not modified by smoking history, but stronger relationships between glutathione S-transferase and NPC were suggested among subjects who used alcohol more frequently than others, older subjects (50 or more years of age), and women relative to men. These data indicate that absence of GSTM1 moderately increases risk for NPC and add to growing evidence that GSTM1 is a determinant of risk for several smoking-related cancers.

UR - http://www.scopus.com/inward/record.url?scp=0033048354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033048354&partnerID=8YFLogxK

M3 - Article

C2 - 10385146

AN - SCOPUS:0033048354

VL - 8

SP - 547

EP - 551

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 6

ER -