Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: A HuGE review and meta-analysis

Zhi Jiang Zhang, Ke Hao, Rong Shi, Genming Zhao, Guo Xin Jiang, Yiqing Song, Xiaohui Xu, Jin Ma

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The association between glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms and oral cancer is not consistent across studies, and data on their interaction with smoking in oral cancer are lacking. The authors systematically searched PubMed and SciVerse Scopus for case-control studies examining the association between null genotypes of the GSTM1 and GSTT1 genes and oral cancer. Twenty-eight case-control studies published in English were identified. Summary odds ratios were derived via random-effects models. The summary odds ratio for the GSTM1 null genotype was 1.43 in Asians (95% confidence interval (CI): 1.14, 1.78; P < 0.01, I 2 = 73%) and 0.98 in Caucasians (95% CI: 0.76, 1.28; P = 0.91, I 2 = 0%). Case-only analysis of 6 studies (552 cases) showed an inverse multiplicative interaction between GSTM1 null polymorphisms and smoking (ever/high levels of smoking vs. never/low levels) (odds ratio (OR) = 0.51, 95% CI: 0.32, 0.82; P = 0.01, I 2 = 34%). The GSTT1 null genotype was not significantly associated with oral cancer in Asians (OR = 1.07, 95% CI: 0.82, 1.38; P = 0.63, I 2 = 65%) or Caucasians (OR = 1.04, 95% CI: 0.41, 2.65; P = 0.93, I 2 = 55%). In conclusion, the GSTM1 null genotype may be associated with a higher risk of oral cancer in Asians but not in Caucasians, and this effect may be modified by smoking status. The GSTT1 null genotype may not be associated with oral cancer.

Original languageEnglish (US)
Pages (from-to)847-857
Number of pages11
JournalAmerican Journal of Epidemiology
Volume173
Issue number8
DOIs
StatePublished - Apr 15 2011
Externally publishedYes

Fingerprint

Mouth Neoplasms
Meta-Analysis
Smoking
Odds Ratio
Genotype
Confidence Intervals
Case-Control Studies
PubMed
glutathione S-transferase M1
glutathione S-transferase T1
Genes

Keywords

  • case-control studies
  • genome, human
  • glutathione transferase
  • interaction
  • meta-analysis
  • mouth neoplasms
  • polymorphism, genetic
  • polymorphism, single nucleotide

ASJC Scopus subject areas

  • Epidemiology

Cite this

Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer : A HuGE review and meta-analysis. / Zhang, Zhi Jiang; Hao, Ke; Shi, Rong; Zhao, Genming; Jiang, Guo Xin; Song, Yiqing; Xu, Xiaohui; Ma, Jin.

In: American Journal of Epidemiology, Vol. 173, No. 8, 15.04.2011, p. 847-857.

Research output: Contribution to journalArticle

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abstract = "The association between glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms and oral cancer is not consistent across studies, and data on their interaction with smoking in oral cancer are lacking. The authors systematically searched PubMed and SciVerse Scopus for case-control studies examining the association between null genotypes of the GSTM1 and GSTT1 genes and oral cancer. Twenty-eight case-control studies published in English were identified. Summary odds ratios were derived via random-effects models. The summary odds ratio for the GSTM1 null genotype was 1.43 in Asians (95{\%} confidence interval (CI): 1.14, 1.78; P < 0.01, I 2 = 73{\%}) and 0.98 in Caucasians (95{\%} CI: 0.76, 1.28; P = 0.91, I 2 = 0{\%}). Case-only analysis of 6 studies (552 cases) showed an inverse multiplicative interaction between GSTM1 null polymorphisms and smoking (ever/high levels of smoking vs. never/low levels) (odds ratio (OR) = 0.51, 95{\%} CI: 0.32, 0.82; P = 0.01, I 2 = 34{\%}). The GSTT1 null genotype was not significantly associated with oral cancer in Asians (OR = 1.07, 95{\%} CI: 0.82, 1.38; P = 0.63, I 2 = 65{\%}) or Caucasians (OR = 1.04, 95{\%} CI: 0.41, 2.65; P = 0.93, I 2 = 55{\%}). In conclusion, the GSTM1 null genotype may be associated with a higher risk of oral cancer in Asians but not in Caucasians, and this effect may be modified by smoking status. The GSTT1 null genotype may not be associated with oral cancer.",
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