Glycogen metabolism and signal transduction in mammals and yeast

Peter Roach, Y. Cao, C. A. Corbett, Anna De Paoli-Roach, I. Farkas, C. J. Fiol, H. Flotow, P. R. Graves, T. A. Hardy, T. W. Hrubey, E. Viskupic, W. Zhang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Mammalian glycogen synthase, with its complex multisite phosphorylation mechanisms, continues to provide interesting and novel examples of the regulation of protein function. The mammalian enzyme is phosphorylated in a hierarchal manner such that modification of certain sites requires the prior phosphorylation of other sites. Yeast contains two glycogen synthases that have extensive similarities to their mammalian counterpart but the greatest divergence in amino acid sequence is seen precisely in the regions likely to be involved in covalent control. We hope that examination of the control of the yeast glycogen synthase will be as informative as study of the mammalian enzymes, whether by revealing important parallels with the mammalian system or by uncovering major differences in mechanism.

Original languageEnglish
Pages (from-to)101-120
Number of pages20
JournalAdvances in Enzyme Regulation
Volume31
Issue numberC
DOIs
StatePublished - 1991

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Glycogen Synthase
Signal transduction
Mammals
Glycogen
Metabolism
Yeast
Signal Transduction
Phosphorylation
Yeasts
Enzymes
Amino Acid Sequence
Amino Acids
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Glycogen metabolism and signal transduction in mammals and yeast. / Roach, Peter; Cao, Y.; Corbett, C. A.; De Paoli-Roach, Anna; Farkas, I.; Fiol, C. J.; Flotow, H.; Graves, P. R.; Hardy, T. A.; Hrubey, T. W.; Viskupic, E.; Zhang, W.

In: Advances in Enzyme Regulation, Vol. 31, No. C, 1991, p. 101-120.

Research output: Contribution to journalArticle

Roach, P, Cao, Y, Corbett, CA, De Paoli-Roach, A, Farkas, I, Fiol, CJ, Flotow, H, Graves, PR, Hardy, TA, Hrubey, TW, Viskupic, E & Zhang, W 1991, 'Glycogen metabolism and signal transduction in mammals and yeast', Advances in Enzyme Regulation, vol. 31, no. C, pp. 101-120. https://doi.org/10.1016/0065-2571(91)90011-A
Roach, Peter ; Cao, Y. ; Corbett, C. A. ; De Paoli-Roach, Anna ; Farkas, I. ; Fiol, C. J. ; Flotow, H. ; Graves, P. R. ; Hardy, T. A. ; Hrubey, T. W. ; Viskupic, E. ; Zhang, W. / Glycogen metabolism and signal transduction in mammals and yeast. In: Advances in Enzyme Regulation. 1991 ; Vol. 31, No. C. pp. 101-120.
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