Glycosylphosphatidyl inositol-linked membrane protein expression by intestinal intraepithelial lymphocytes

Bernard De Geus, Harm Hogenesch, Ralph T. Kubo, Jan Rozing

Research output: Contribution to journalArticle

2 Scopus citations


Murlne intestinal intraepithelial lymphocytes (IIEL) represent a heterogeneous population of cells which contains both TCRαβ+ and TCRγδ+ cells. In contrast to the TCRαβ+ cell population in peripheral lymphoid organs, the TCRαβ+ IIEL contain high numbers of Thy-1- cells. This negativity of IIEL for Thy-1, a glycosylphosphatkiyl inositol (GPI)-linked membrane protein, is not the result of conformatlonal changes of the Thy-1 molecule. The absence of Thy-1 on TCRγδ+ and a subset of TCRαβ+ IIEL Is furthermore not caused by a general defect In the processing of GPI-linked proteins, since Thy-1- IIEL mainly express another GPI-linked protein, Qa-2. However, TCRαβ+ and TCRγδ+ IIEL are also virtually negative for two other members of this family of activation-associated GPI-linked proteins, Ly-6A and Ly-6C. This unusual pattern of GPI-linked protein expression on TCR+ IIEL may be related to differences In cellular activation and signal transduction pathways between TCR+ IIEL and regular peripheral T cells.

Original languageEnglish (US)
Pages (from-to)899-903
Number of pages5
JournalInternational immunology
Issue number8
StatePublished - Aug 1 1992
Externally publishedYes


  • Glycosylphosphatdyl inositol
  • T cell activation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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