Glycosylphosphatidyl inositol-linked membrane protein expression by intestinal intraepithelial lymphocytes

Bernard De Geus, Harm Hogenesch, Ralph T. Kubo, Jan Rozing

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Murlne intestinal intraepithelial lymphocytes (IIEL) represent a heterogeneous population of cells which contains both TCRαβ+ and TCRγδ+ cells. In contrast to the TCRαβ+ cell population in peripheral lymphoid organs, the TCRαβ+ IIEL contain high numbers of Thy-1- cells. This negativity of IIEL for Thy-1, a glycosylphosphatkiyl inositol (GPI)-linked membrane protein, is not the result of conformatlonal changes of the Thy-1 molecule. The absence of Thy-1 on TCRγδ+ and a subset of TCRαβ+ IIEL Is furthermore not caused by a general defect In the processing of GPI-linked proteins, since Thy-1- IIEL mainly express another GPI-linked protein, Qa-2. However, TCRαβ+ and TCRγδ+ IIEL are also virtually negative for two other members of this family of activation-associated GPI-linked proteins, Ly-6A and Ly-6C. This unusual pattern of GPI-linked protein expression on TCR+ IIEL may be related to differences In cellular activation and signal transduction pathways between TCR+ IIEL and regular peripheral T cells.

Original languageEnglish (US)
Pages (from-to)899-903
Number of pages5
JournalInternational immunology
Volume4
Issue number8
DOIs
StatePublished - Aug 1 1992

Fingerprint

Membrane Protein
Lymphocytes
Inositol
Membrane Proteins
Proteins
Membranes
Protein
Activation
Cell
Chemical activation
Cells
Signal transduction
T-cells
Signal Transduction
Membrane
Cell Population
Population
Pathway
Express
Defects

Keywords

  • Glycosylphosphatdyl inositol
  • T cell activation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Glycosylphosphatidyl inositol-linked membrane protein expression by intestinal intraepithelial lymphocytes. / Geus, Bernard De; Hogenesch, Harm; Kubo, Ralph T.; Rozing, Jan.

In: International immunology, Vol. 4, No. 8, 01.08.1992, p. 899-903.

Research output: Contribution to journalArticle

@article{dad2fdbc2f9e48ed9e4e391a6557a8b2,
title = "Glycosylphosphatidyl inositol-linked membrane protein expression by intestinal intraepithelial lymphocytes",
abstract = "Murlne intestinal intraepithelial lymphocytes (IIEL) represent a heterogeneous population of cells which contains both TCRαβ+ and TCRγδ+ cells. In contrast to the TCRαβ+ cell population in peripheral lymphoid organs, the TCRαβ+ IIEL contain high numbers of Thy-1- cells. This negativity of IIEL for Thy-1, a glycosylphosphatkiyl inositol (GPI)-linked membrane protein, is not the result of conformatlonal changes of the Thy-1 molecule. The absence of Thy-1 on TCRγδ+ and a subset of TCRαβ+ IIEL Is furthermore not caused by a general defect In the processing of GPI-linked proteins, since Thy-1- IIEL mainly express another GPI-linked protein, Qa-2. However, TCRαβ+ and TCRγδ+ IIEL are also virtually negative for two other members of this family of activation-associated GPI-linked proteins, Ly-6A and Ly-6C. This unusual pattern of GPI-linked protein expression on TCR+ IIEL may be related to differences In cellular activation and signal transduction pathways between TCR+ IIEL and regular peripheral T cells.",
keywords = "Glycosylphosphatdyl inositol, T cell activation",
author = "Geus, {Bernard De} and Harm Hogenesch and Kubo, {Ralph T.} and Jan Rozing",
year = "1992",
month = "8",
day = "1",
doi = "10.1093/intimm/4.8.899",
language = "English (US)",
volume = "4",
pages = "899--903",
journal = "International Immunology",
issn = "0953-8178",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Glycosylphosphatidyl inositol-linked membrane protein expression by intestinal intraepithelial lymphocytes

AU - Geus, Bernard De

AU - Hogenesch, Harm

AU - Kubo, Ralph T.

AU - Rozing, Jan

PY - 1992/8/1

Y1 - 1992/8/1

N2 - Murlne intestinal intraepithelial lymphocytes (IIEL) represent a heterogeneous population of cells which contains both TCRαβ+ and TCRγδ+ cells. In contrast to the TCRαβ+ cell population in peripheral lymphoid organs, the TCRαβ+ IIEL contain high numbers of Thy-1- cells. This negativity of IIEL for Thy-1, a glycosylphosphatkiyl inositol (GPI)-linked membrane protein, is not the result of conformatlonal changes of the Thy-1 molecule. The absence of Thy-1 on TCRγδ+ and a subset of TCRαβ+ IIEL Is furthermore not caused by a general defect In the processing of GPI-linked proteins, since Thy-1- IIEL mainly express another GPI-linked protein, Qa-2. However, TCRαβ+ and TCRγδ+ IIEL are also virtually negative for two other members of this family of activation-associated GPI-linked proteins, Ly-6A and Ly-6C. This unusual pattern of GPI-linked protein expression on TCR+ IIEL may be related to differences In cellular activation and signal transduction pathways between TCR+ IIEL and regular peripheral T cells.

AB - Murlne intestinal intraepithelial lymphocytes (IIEL) represent a heterogeneous population of cells which contains both TCRαβ+ and TCRγδ+ cells. In contrast to the TCRαβ+ cell population in peripheral lymphoid organs, the TCRαβ+ IIEL contain high numbers of Thy-1- cells. This negativity of IIEL for Thy-1, a glycosylphosphatkiyl inositol (GPI)-linked membrane protein, is not the result of conformatlonal changes of the Thy-1 molecule. The absence of Thy-1 on TCRγδ+ and a subset of TCRαβ+ IIEL Is furthermore not caused by a general defect In the processing of GPI-linked proteins, since Thy-1- IIEL mainly express another GPI-linked protein, Qa-2. However, TCRαβ+ and TCRγδ+ IIEL are also virtually negative for two other members of this family of activation-associated GPI-linked proteins, Ly-6A and Ly-6C. This unusual pattern of GPI-linked protein expression on TCR+ IIEL may be related to differences In cellular activation and signal transduction pathways between TCR+ IIEL and regular peripheral T cells.

KW - Glycosylphosphatdyl inositol

KW - T cell activation

UR - http://www.scopus.com/inward/record.url?scp=0026752840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026752840&partnerID=8YFLogxK

U2 - 10.1093/intimm/4.8.899

DO - 10.1093/intimm/4.8.899

M3 - Article

C2 - 1358188

AN - SCOPUS:0026752840

VL - 4

SP - 899

EP - 903

JO - International Immunology

JF - International Immunology

SN - 0953-8178

IS - 8

ER -