Nearly half of all bladder tumors are noninvasive (stage pTa) papillary neoplasms of urothelial origin. Histologic grading is one of the most important variables for a clinician to successfully manage such patients. However, contemporary classification and grading of papillary urothelial neoplasms remains unsettled. The purpose of this article is to provide current information with an emphasis on grade 1 urothelial carcinoma versus papillary urothelial carcinoma of low malignant potential (PUNLMP). The World Health Organization [WHO (1973)] classification for papillary urothelial neoplasms (papilloma, grade 1, grade 2, and grade 3 carcinoma) is still most often used compared with existing alternatives [such as WHO/International Society of Urological Pathology (1998), WHO (1999), and WHO (2004)]. The new terminology (PUNLMP) used in the WHO (2004) classification is of unproven validity and utility. Recent advances in the molecular grading of these tumors may soon supplant traditional morphologic classification, allowing a more precise and objective assessment of the biologic potential of these tumors.
- Histologic grading
- Papillary urothelial neoplasm
- WHO classification
ASJC Scopus subject areas
- Pathology and Forensic Medicine