Grading and staging of bladder carcinoma in transurethral resection specimens: Correlation with 105 matched cystectomy specimens

Liang Cheng, Roxann M. Neumann, Amy L. Weaver, John C. Cheville, Bradley C. Leibovich, Dharamdas M. Ramnani, Beth G. Scherer, Ajay Nehra, Horst Zincke, David G. Bostwick

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

We compared the grading and staging of transurethral resection of the bladder (TURB) and cystectomy specimens for 105 patients who underwent radical cystectomy for urothelial carcinoma between 1980 and 1984. Of 105 patients, 96% underwent cystectomy within 100 days of TURB (median interval, 10 days). Grading was performed according to the 1998 World Health Organization/International Society of Urologic Pathology grading system and staging according to the 1997 TNM classification. Histologic grade was low- grade, 13; high-grade, 92 in TURB specimens; low-grade, 17; high-grade, 88 in cystectomy specimens. Pathologic stage was Ta, 15; T1, 55; and T2, 35 in TURB specimens; Ta, 5; T1, 19; T2, 19; T3, 46; and T4, 16 in cystectomy specimens. Histologic grade at TURB was associated with pathologic stage at cystectomy (P < .001). When all advanced-stage (muscle-invasive) carcinomas (pT2 or more) were considered together, 55 patients were understaged by TURB, 4 had higher stage in TURB than in cystectomy, and 46 were the same stage as by cystectomy. Forty-three of 55 patients with stage T1 carcinoma at TURB had advanced-stage carcinoma at cystectomy, including 34 who had extravesicular extension (pT3 or more). We found pathologic understaging by TURB occurs in a significant number of patients with bladder cancer; the newly proposed grading system predicted final pathologic stage.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume113
Issue number2
StatePublished - 2000

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Cystectomy
Urinary Bladder
Carcinoma
Neoplasm Staging
Urinary Bladder Neoplasms
Pathology
Muscles

Keywords

  • Bladder
  • Carcinoma
  • Cystectomy
  • Grading
  • Muscle invasion
  • Staging
  • Transurethral resection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Cheng, L., Neumann, R. M., Weaver, A. L., Cheville, J. C., Leibovich, B. C., Ramnani, D. M., ... Bostwick, D. G. (2000). Grading and staging of bladder carcinoma in transurethral resection specimens: Correlation with 105 matched cystectomy specimens. American Journal of Clinical Pathology, 113(2), 275-279.

Grading and staging of bladder carcinoma in transurethral resection specimens : Correlation with 105 matched cystectomy specimens. / Cheng, Liang; Neumann, Roxann M.; Weaver, Amy L.; Cheville, John C.; Leibovich, Bradley C.; Ramnani, Dharamdas M.; Scherer, Beth G.; Nehra, Ajay; Zincke, Horst; Bostwick, David G.

In: American Journal of Clinical Pathology, Vol. 113, No. 2, 2000, p. 275-279.

Research output: Contribution to journalArticle

Cheng, L, Neumann, RM, Weaver, AL, Cheville, JC, Leibovich, BC, Ramnani, DM, Scherer, BG, Nehra, A, Zincke, H & Bostwick, DG 2000, 'Grading and staging of bladder carcinoma in transurethral resection specimens: Correlation with 105 matched cystectomy specimens', American Journal of Clinical Pathology, vol. 113, no. 2, pp. 275-279.
Cheng, Liang ; Neumann, Roxann M. ; Weaver, Amy L. ; Cheville, John C. ; Leibovich, Bradley C. ; Ramnani, Dharamdas M. ; Scherer, Beth G. ; Nehra, Ajay ; Zincke, Horst ; Bostwick, David G. / Grading and staging of bladder carcinoma in transurethral resection specimens : Correlation with 105 matched cystectomy specimens. In: American Journal of Clinical Pathology. 2000 ; Vol. 113, No. 2. pp. 275-279.
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