Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function

Wei Zhang, Wei Hua Lee, Lazaros C. Triarhou

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Fetal grafts of normal cerebellar tissue were implanted into the cerebellum of Purkinje cell degeneration mutant mice (pcd/pcd), a model of adult-onset recessively inherited cerebello-olivary atrophy, in an attempt at correcting their cellular and motor impairment. Donor cerebellar cells engrafted in the appropriate sites, as evidenced by the pattern of expression of insulin-like growth factor-I (ICF-I) system genes. Bilateral cerebellar grafts led to an improvement of motor behaviors in balance rod tests and in the open field, providing evidence for functional integration into the atrophic mouse cerebellum and underscoring the potential of neural transplantation for counteracting the human cerebellar ataxias.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalNature Medicine
Volume2
Issue number1
DOIs
StatePublished - 1996

Fingerprint

Spinocerebellar Degenerations
Insulin-Like Growth Factor I
Grafts
Cerebellum
Genes
Transplants
Cerebellar Ataxia
Purkinje Cells
Atrophy
Transplantation
Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function. / Zhang, Wei; Lee, Wei Hua; Triarhou, Lazaros C.

In: Nature Medicine, Vol. 2, No. 1, 1996, p. 65-71.

Research output: Contribution to journalArticle

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