Graphene oxide-based biosensors for liquid biopsies in cancer diagnosis

Shiue Luen Chen, Chong You Chen, Jason Chia Hsun Hsieh, Zih Yu Yu, Sheng Jen Cheng, Kuan Yu Hsieh, Jia Wei Yang, Priyank V. Kumar, Shien Fong Lin, Guan Yu Chen

Research output: Contribution to journalReview article

Abstract

Liquid biopsies use blood or urine as test samples, which are able to be continuously collected in a non-invasive manner. The analysis of cancer-related biomarkers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA, and exosomes provides important information in early cancer diagnosis, tumor metastasis detection, and postoperative recurrence monitoring assist with clinical diagnosis. However, low concentrations of some tumor markers, such as CTCs, ctDNA, and microRNA, in the blood limit its applications in clinical detection and analysis. Nanomaterials based on graphene oxide have good physicochemical properties and are now widely used in biomedical detection technologies. These materials have properties including good hydrophilicity, mechanical flexibility, electrical conductivity, biocompatibility, and optical performance. Moreover, utilizing graphene oxide as a biosensor interface has effectively improved the sensitivity and specificity of biosensors for cancer detection. In this review, we discuss various cancer detection technologies regarding graphene oxide and discuss the prospects and challenges of this technology.

Original languageEnglish (US)
Article number1725
JournalNanomaterials
Volume9
Issue number12
DOIs
StatePublished - Dec 2019

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Keywords

  • Circulating tumor DNA
  • Circulating tumor cells
  • Exosome
  • Graphene oxide
  • Liquid biopsy

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

Cite this

Chen, S. L., Chen, C. Y., Hsieh, J. C. H., Yu, Z. Y., Cheng, S. J., Hsieh, K. Y., Yang, J. W., Kumar, P. V., Lin, S. F., & Chen, G. Y. (2019). Graphene oxide-based biosensors for liquid biopsies in cancer diagnosis. Nanomaterials, 9(12), [1725]. https://doi.org/10.3390/nano9121725