Graphic Mining of High-Order Drug Interactions and Their Directional Effects on Myopathy Using Electronic Medical Records

L. Du, A. Chakraborty, C. W. Chiang, Liang Cheng, Sara Quinney, H. Wu, P. Zhang, L. Li, Li Shen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We propose to study a novel pharmacovigilance problem for mining directional effects of high-order drug interactions on an adverse drug event (ADE). Our goal is to estimate each individual risk of adding a new drug to an existing drug combination. In this proof-of-concept study, we analyzed a large electronic medical records database and extracted myopathy-relevant case control drug co-occurrence data. We applied frequent itemset mining to discover frequent drug combinations within the extracted data, evaluated directional drug interactions related to these combinations, and identified directional drug interactions with large effect sizes. Furthermore, we developed a novel visualization method to organize multiple directional drug interaction effects depicted as a tree, to generate an intuitive graphical and visual representation of our data-mining results. This translational bioinformatics approach yields promising results, adds valuable and complementary information to the existing pharmacovigilance literature, and has the potential to impact clinical practice.

Original languageEnglish (US)
Pages (from-to)481-488
Number of pages8
JournalCPT: Pharmacometrics and Systems Pharmacology
Volume4
Issue number8
DOIs
StatePublished - Aug 1 2015

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Drug interactions
Electronic medical equipment
Electronic Health Records
Muscular Diseases
Drug Interactions
Mining
Drugs
Electronics
Higher Order
Pharmacovigilance
Drug Combinations
Interaction
Data Mining
Drug and Narcotic Control
Bioinformatics
Computational Biology
Drug-Related Side Effects and Adverse Reactions
Data mining
Visualization
Databases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Graphic Mining of High-Order Drug Interactions and Their Directional Effects on Myopathy Using Electronic Medical Records. / Du, L.; Chakraborty, A.; Chiang, C. W.; Cheng, Liang; Quinney, Sara; Wu, H.; Zhang, P.; Li, L.; Shen, Li.

In: CPT: Pharmacometrics and Systems Pharmacology, Vol. 4, No. 8, 01.08.2015, p. 481-488.

Research output: Contribution to journalArticle

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