Groin dissection versus groin radiation in carcinoma of the vulva: A gynecologic oncology group study

Frederick Stehman, Brian N. Bundy, Gillian Thomas, Mahesh Varia, Takashi Okagaki, James Roberts, Jeffrey Bell, Paul B. Heller

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Purpose: The objective of this study was to determine if groin radiation was superior to and less morbid than groin dissection. Methods and Materials: Members of the Gynecologic Oncology Group randomized 58 patients with squamous carcinoma of the vulva and nonsuspicious (N0-1) inguinal nodes to receive either groin dissection or groin radiation, each in conjunction with radical vulvectomy. 3|'Radiation therapy consisted of a dose of 50 Gray given in daily 200 centiGray fractions to a depth of 3 cm below the anterior skin surface. Results: The study was closed prematurely when interim monitoring revealed an excessive number of groin relapses on the groin radiation regimen. Metastatic involvement of the groin nodes was projected to occur in 24% of patients based on this Group's previous experience. On the groin dissection regimen, there were 5 25 (20.0%) patients with positive groin nodes. These patients received post-operative radiation. There were five groin relapses among the 27 (18.5%) patients on the groin radiation regimen and none on the groin dissection regimen. The groin dissection regimen had significantly better progression-free interval (p = 0.03) and survival (p = 0.04). Conclusion: Radiation of the intact groins as given in this study is significantly inferior to groin dissection in patients with squamous carcinoma of the vulva and (N0-1) nodes.

Original languageEnglish
Pages (from-to)389-396
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume24
Issue number2
DOIs
StatePublished - 1992

Fingerprint

dissection
Vulva
Groin
Dissection
cancer
Radiation
Carcinoma
radiation
progressions
radiation therapy
intervals
Squamous Cell Carcinoma
dosage
Recurrence

Keywords

  • Carcinoma of the vulva
  • Groin dissection
  • Groin radiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Groin dissection versus groin radiation in carcinoma of the vulva : A gynecologic oncology group study. / Stehman, Frederick; Bundy, Brian N.; Thomas, Gillian; Varia, Mahesh; Okagaki, Takashi; Roberts, James; Bell, Jeffrey; Heller, Paul B.

In: International Journal of Radiation Oncology Biology Physics, Vol. 24, No. 2, 1992, p. 389-396.

Research output: Contribution to journalArticle

Stehman, Frederick ; Bundy, Brian N. ; Thomas, Gillian ; Varia, Mahesh ; Okagaki, Takashi ; Roberts, James ; Bell, Jeffrey ; Heller, Paul B. / Groin dissection versus groin radiation in carcinoma of the vulva : A gynecologic oncology group study. In: International Journal of Radiation Oncology Biology Physics. 1992 ; Vol. 24, No. 2. pp. 389-396.
@article{97a8b4ec15794188a35b5690170f8059,
title = "Groin dissection versus groin radiation in carcinoma of the vulva: A gynecologic oncology group study",
abstract = "Purpose: The objective of this study was to determine if groin radiation was superior to and less morbid than groin dissection. Methods and Materials: Members of the Gynecologic Oncology Group randomized 58 patients with squamous carcinoma of the vulva and nonsuspicious (N0-1) inguinal nodes to receive either groin dissection or groin radiation, each in conjunction with radical vulvectomy. 3|'Radiation therapy consisted of a dose of 50 Gray given in daily 200 centiGray fractions to a depth of 3 cm below the anterior skin surface. Results: The study was closed prematurely when interim monitoring revealed an excessive number of groin relapses on the groin radiation regimen. Metastatic involvement of the groin nodes was projected to occur in 24{\%} of patients based on this Group's previous experience. On the groin dissection regimen, there were 5 25 (20.0{\%}) patients with positive groin nodes. These patients received post-operative radiation. There were five groin relapses among the 27 (18.5{\%}) patients on the groin radiation regimen and none on the groin dissection regimen. The groin dissection regimen had significantly better progression-free interval (p = 0.03) and survival (p = 0.04). Conclusion: Radiation of the intact groins as given in this study is significantly inferior to groin dissection in patients with squamous carcinoma of the vulva and (N0-1) nodes.",
keywords = "Carcinoma of the vulva, Groin dissection, Groin radiation",
author = "Frederick Stehman and Bundy, {Brian N.} and Gillian Thomas and Mahesh Varia and Takashi Okagaki and James Roberts and Jeffrey Bell and Heller, {Paul B.}",
year = "1992",
doi = "10.1016/0360-3016(92)90699-I",
language = "English",
volume = "24",
pages = "389--396",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Groin dissection versus groin radiation in carcinoma of the vulva

T2 - A gynecologic oncology group study

AU - Stehman, Frederick

AU - Bundy, Brian N.

AU - Thomas, Gillian

AU - Varia, Mahesh

AU - Okagaki, Takashi

AU - Roberts, James

AU - Bell, Jeffrey

AU - Heller, Paul B.

PY - 1992

Y1 - 1992

N2 - Purpose: The objective of this study was to determine if groin radiation was superior to and less morbid than groin dissection. Methods and Materials: Members of the Gynecologic Oncology Group randomized 58 patients with squamous carcinoma of the vulva and nonsuspicious (N0-1) inguinal nodes to receive either groin dissection or groin radiation, each in conjunction with radical vulvectomy. 3|'Radiation therapy consisted of a dose of 50 Gray given in daily 200 centiGray fractions to a depth of 3 cm below the anterior skin surface. Results: The study was closed prematurely when interim monitoring revealed an excessive number of groin relapses on the groin radiation regimen. Metastatic involvement of the groin nodes was projected to occur in 24% of patients based on this Group's previous experience. On the groin dissection regimen, there were 5 25 (20.0%) patients with positive groin nodes. These patients received post-operative radiation. There were five groin relapses among the 27 (18.5%) patients on the groin radiation regimen and none on the groin dissection regimen. The groin dissection regimen had significantly better progression-free interval (p = 0.03) and survival (p = 0.04). Conclusion: Radiation of the intact groins as given in this study is significantly inferior to groin dissection in patients with squamous carcinoma of the vulva and (N0-1) nodes.

AB - Purpose: The objective of this study was to determine if groin radiation was superior to and less morbid than groin dissection. Methods and Materials: Members of the Gynecologic Oncology Group randomized 58 patients with squamous carcinoma of the vulva and nonsuspicious (N0-1) inguinal nodes to receive either groin dissection or groin radiation, each in conjunction with radical vulvectomy. 3|'Radiation therapy consisted of a dose of 50 Gray given in daily 200 centiGray fractions to a depth of 3 cm below the anterior skin surface. Results: The study was closed prematurely when interim monitoring revealed an excessive number of groin relapses on the groin radiation regimen. Metastatic involvement of the groin nodes was projected to occur in 24% of patients based on this Group's previous experience. On the groin dissection regimen, there were 5 25 (20.0%) patients with positive groin nodes. These patients received post-operative radiation. There were five groin relapses among the 27 (18.5%) patients on the groin radiation regimen and none on the groin dissection regimen. The groin dissection regimen had significantly better progression-free interval (p = 0.03) and survival (p = 0.04). Conclusion: Radiation of the intact groins as given in this study is significantly inferior to groin dissection in patients with squamous carcinoma of the vulva and (N0-1) nodes.

KW - Carcinoma of the vulva

KW - Groin dissection

KW - Groin radiation

UR - http://www.scopus.com/inward/record.url?scp=0026805998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026805998&partnerID=8YFLogxK

U2 - 10.1016/0360-3016(92)90699-I

DO - 10.1016/0360-3016(92)90699-I

M3 - Article

C2 - 1526880

AN - SCOPUS:0026805998

VL - 24

SP - 389

EP - 396

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 2

ER -