Growth deficits in a postnatal day 3 rat model of hypoxic-ischemic brain injury

Wei Cheng Tai, Kathleen A. Burke, Jesus F. Dominguez, Lalitha Gundamraj, Jack E. Turman

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The postnatal day (P) 3 rat model of hypoxic-ischemic (HI) brain injury provides valuable information regarding the cellular response to HI injury in a very immature brain. Our present study is the first to examine growth, metabolic, and behavioral outcomes following a P3 HI brain injury. Rats were injured by cauterizing the right common carotid, and exposure to 8% oxygen for 1.5 h. Control rats received sham surgery and exposure to 1.5 h of room air. One cohort of rats was examined for growth patterns through P33, evaluated using a battery of tests focused on early postnatal feeding behaviors, and studied using the open field paradigm during the early postnatal and postweaning periods. Another cohort of rats was used to examine metabolic parameters using indirect calorimetry. Significant growth deficits emerged in injured rats during the second postnatal week. No significant differences between groups were noted in the expression of feeding-related behaviors or in metabolic parameters between groups. However, we did observe significant associations between feeding-related behaviors and P14 growth parameters in injured rats. In the open field assessment, HI rats showed increased circling and supination behaviors only during the early postnatal period. Our data reveal that P3 HI brain injury results in generalized growth deficits that persist through postweaning. Analyses suggest that alterations in feeding-related behaviors contribute to growth deficits following a P3 HI brain injury.

Original languageEnglish (US)
Pages (from-to)40-49
Number of pages10
JournalBehavioural Brain Research
Volume202
Issue number1
DOIs
StatePublished - Aug 24 2009

Fingerprint

Brain Injuries
Feeding Behavior
Growth
Supination
Indirect Calorimetry
Air
Oxygen
Wounds and Injuries
Brain

Keywords

  • Feeding
  • Indirect calorimetry
  • Metabolism
  • Open field

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Growth deficits in a postnatal day 3 rat model of hypoxic-ischemic brain injury. / Tai, Wei Cheng; Burke, Kathleen A.; Dominguez, Jesus F.; Gundamraj, Lalitha; Turman, Jack E.

In: Behavioural Brain Research, Vol. 202, No. 1, 24.08.2009, p. 40-49.

Research output: Contribution to journalArticle

Tai, Wei Cheng ; Burke, Kathleen A. ; Dominguez, Jesus F. ; Gundamraj, Lalitha ; Turman, Jack E. / Growth deficits in a postnatal day 3 rat model of hypoxic-ischemic brain injury. In: Behavioural Brain Research. 2009 ; Vol. 202, No. 1. pp. 40-49.
@article{409d6197935b480d9fb54d7a774afabc,
title = "Growth deficits in a postnatal day 3 rat model of hypoxic-ischemic brain injury",
abstract = "The postnatal day (P) 3 rat model of hypoxic-ischemic (HI) brain injury provides valuable information regarding the cellular response to HI injury in a very immature brain. Our present study is the first to examine growth, metabolic, and behavioral outcomes following a P3 HI brain injury. Rats were injured by cauterizing the right common carotid, and exposure to 8{\%} oxygen for 1.5 h. Control rats received sham surgery and exposure to 1.5 h of room air. One cohort of rats was examined for growth patterns through P33, evaluated using a battery of tests focused on early postnatal feeding behaviors, and studied using the open field paradigm during the early postnatal and postweaning periods. Another cohort of rats was used to examine metabolic parameters using indirect calorimetry. Significant growth deficits emerged in injured rats during the second postnatal week. No significant differences between groups were noted in the expression of feeding-related behaviors or in metabolic parameters between groups. However, we did observe significant associations between feeding-related behaviors and P14 growth parameters in injured rats. In the open field assessment, HI rats showed increased circling and supination behaviors only during the early postnatal period. Our data reveal that P3 HI brain injury results in generalized growth deficits that persist through postweaning. Analyses suggest that alterations in feeding-related behaviors contribute to growth deficits following a P3 HI brain injury.",
keywords = "Feeding, Indirect calorimetry, Metabolism, Open field",
author = "Tai, {Wei Cheng} and Burke, {Kathleen A.} and Dominguez, {Jesus F.} and Lalitha Gundamraj and Turman, {Jack E.}",
year = "2009",
month = "8",
day = "24",
doi = "10.1016/j.bbr.2009.03.043",
language = "English (US)",
volume = "202",
pages = "40--49",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Growth deficits in a postnatal day 3 rat model of hypoxic-ischemic brain injury

AU - Tai, Wei Cheng

AU - Burke, Kathleen A.

AU - Dominguez, Jesus F.

AU - Gundamraj, Lalitha

AU - Turman, Jack E.

PY - 2009/8/24

Y1 - 2009/8/24

N2 - The postnatal day (P) 3 rat model of hypoxic-ischemic (HI) brain injury provides valuable information regarding the cellular response to HI injury in a very immature brain. Our present study is the first to examine growth, metabolic, and behavioral outcomes following a P3 HI brain injury. Rats were injured by cauterizing the right common carotid, and exposure to 8% oxygen for 1.5 h. Control rats received sham surgery and exposure to 1.5 h of room air. One cohort of rats was examined for growth patterns through P33, evaluated using a battery of tests focused on early postnatal feeding behaviors, and studied using the open field paradigm during the early postnatal and postweaning periods. Another cohort of rats was used to examine metabolic parameters using indirect calorimetry. Significant growth deficits emerged in injured rats during the second postnatal week. No significant differences between groups were noted in the expression of feeding-related behaviors or in metabolic parameters between groups. However, we did observe significant associations between feeding-related behaviors and P14 growth parameters in injured rats. In the open field assessment, HI rats showed increased circling and supination behaviors only during the early postnatal period. Our data reveal that P3 HI brain injury results in generalized growth deficits that persist through postweaning. Analyses suggest that alterations in feeding-related behaviors contribute to growth deficits following a P3 HI brain injury.

AB - The postnatal day (P) 3 rat model of hypoxic-ischemic (HI) brain injury provides valuable information regarding the cellular response to HI injury in a very immature brain. Our present study is the first to examine growth, metabolic, and behavioral outcomes following a P3 HI brain injury. Rats were injured by cauterizing the right common carotid, and exposure to 8% oxygen for 1.5 h. Control rats received sham surgery and exposure to 1.5 h of room air. One cohort of rats was examined for growth patterns through P33, evaluated using a battery of tests focused on early postnatal feeding behaviors, and studied using the open field paradigm during the early postnatal and postweaning periods. Another cohort of rats was used to examine metabolic parameters using indirect calorimetry. Significant growth deficits emerged in injured rats during the second postnatal week. No significant differences between groups were noted in the expression of feeding-related behaviors or in metabolic parameters between groups. However, we did observe significant associations between feeding-related behaviors and P14 growth parameters in injured rats. In the open field assessment, HI rats showed increased circling and supination behaviors only during the early postnatal period. Our data reveal that P3 HI brain injury results in generalized growth deficits that persist through postweaning. Analyses suggest that alterations in feeding-related behaviors contribute to growth deficits following a P3 HI brain injury.

KW - Feeding

KW - Indirect calorimetry

KW - Metabolism

KW - Open field

UR - http://www.scopus.com/inward/record.url?scp=65549150975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549150975&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2009.03.043

DO - 10.1016/j.bbr.2009.03.043

M3 - Article

C2 - 19447279

AN - SCOPUS:65549150975

VL - 202

SP - 40

EP - 49

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -