Growth factors and articular cartilage.

H. J. Mankin, L. C. Jennings, B. V. Treadwell, Stephen Trippel

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Studies of articular cartilage over the decades have demonstrated a surprisingly brisk rate of synthesis of the matrix proteins which appears to vary considerably with metabolic, physicochemical and pathological state of the tissue. It has become evident that much of this activity is directed by low molecular weight protein mediators which act at specific receptor sites. Platelet derived growth factor (PDGF) is of limited action in normal cartilage, but insulin and its analogues, insulin growth factor-I and II are powerful stimulants of DNA synthesis. Basic fibroblast growth factor stimulates both DNA and protein synthesis and works synergistically with other factors. Transforming growth factor beta potentiates the action of the mitogens and enhances and regulates proteoglycan synthesis. These actions may be of special importance in osteoarthritis and lacerative injury to cartilage.

Original languageEnglish (US)
Pages (from-to)66-67
Number of pages2
JournalThe Journal of rheumatology. Supplement
Volume27
StatePublished - Feb 1991
Externally publishedYes

Fingerprint

Articular Cartilage
Intercellular Signaling Peptides and Proteins
Cartilage
Insulin
Proteins
DNA
Platelet-Derived Growth Factor
Fibroblast Growth Factor 2
Proteoglycans
Mitogens
Osteoarthritis
Transforming Growth Factor beta
Molecular Weight
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology
  • Rheumatology

Cite this

Mankin, H. J., Jennings, L. C., Treadwell, B. V., & Trippel, S. (1991). Growth factors and articular cartilage. The Journal of rheumatology. Supplement, 27, 66-67.

Growth factors and articular cartilage. / Mankin, H. J.; Jennings, L. C.; Treadwell, B. V.; Trippel, Stephen.

In: The Journal of rheumatology. Supplement, Vol. 27, 02.1991, p. 66-67.

Research output: Contribution to journalArticle

Mankin, HJ, Jennings, LC, Treadwell, BV & Trippel, S 1991, 'Growth factors and articular cartilage.', The Journal of rheumatology. Supplement, vol. 27, pp. 66-67.
Mankin HJ, Jennings LC, Treadwell BV, Trippel S. Growth factors and articular cartilage. The Journal of rheumatology. Supplement. 1991 Feb;27:66-67.
Mankin, H. J. ; Jennings, L. C. ; Treadwell, B. V. ; Trippel, Stephen. / Growth factors and articular cartilage. In: The Journal of rheumatology. Supplement. 1991 ; Vol. 27. pp. 66-67.
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