Growth factors and pancreatic cancer

Murray Korc

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Cultured human pancreatic cancer cells produce a number of growth factors, including transforming growth factor-α (TGF-α). These cells also overexpress the epidermal growth factor (EGF) receptor and exhibit a parallel increase in EGF receptor mRNA levels. TGF-α, which binds to the EGF receptor, is more potent than EGF in enhancing the anchorage-independent growth of several pancreatic cancer cell lines, including T3M4 cells. In contrast, EGF is more efficient than TGF-α with respect to EGF receptor downregulation and tyrosine phosphorylation in T3M4 cells. Further, T3M4 cells recycle EGF, but markedly degrade TGF-α. It is suggested that the production of multiple growth factors, the overexpression of the EGF receptor, the recycling of EGF, and the attenuated ability of TGF-α to downregulate the EGF receptor combine to enhance the growth advantage of human pancreatic cancer cells.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalInternational Journal of Pancreatology
Volume9
Issue number1
DOIs
StatePublished - Jun 1991

Keywords

  • Epidermal growth factor receptor
  • pancreatic cancer
  • transforming growth factor-α

ASJC Scopus subject areas

  • Oncology
  • Endocrinology
  • Gastroenterology

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