Growth factors and pancreatic cancer

Murray Korc

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cultured human pancreatic cancer cells produce a number of growth factors, including transforming growth factor-α (TGF-α). These cells also overexpress the epidermal growth factor (EGF) receptor and exhibit a parallel increase in EGF receptor mRNA levels. TGF-α, which binds to the EGF receptor, is more potent than EGF in enhancing the anchorage-independent growth of several pancreatic cancer cell lines, including T3M4 cells. In contrast, EGF is more efficient than TGF-α with respect to EGF receptor downregulation and tyrosine phosphorylation in T3M4 cells. Further, T3M4 cells recycle EGF, but markedly degrade TGF-α. It is suggested that the production of multiple growth factors, the overexpression of the EGF receptor, the recycling of EGF, and the attenuated ability of TGF-α to downregulate the EGF receptor combine to enhance the growth advantage of human pancreatic cancer cells.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalInternational Journal of Pancreatology
Volume9
Issue number1
DOIs
StatePublished - Jun 1991
Externally publishedYes

Fingerprint

Pancreatic Neoplasms
Epidermal Growth Factor Receptor
Transforming Growth Factors
Intercellular Signaling Peptides and Proteins
Epidermal Growth Factor
Down-Regulation
Recycling
Growth
Tyrosine
Phosphorylation
Cell Line
Messenger RNA

Keywords

  • Epidermal growth factor receptor
  • pancreatic cancer
  • transforming growth factor-α

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

Cite this

Growth factors and pancreatic cancer. / Korc, Murray.

In: International Journal of Pancreatology, Vol. 9, No. 1, 06.1991, p. 87-91.

Research output: Contribution to journalArticle

Korc, Murray. / Growth factors and pancreatic cancer. In: International Journal of Pancreatology. 1991 ; Vol. 9, No. 1. pp. 87-91.
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