Growth hormone releasing factor in human cerebrospinal fluid

Wade H. Berrettini, John Nurnberger, Susan Simmons-Alling

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Growth hormone releasing factor (GHRF) was determined by radio-immunoassay in cerebrospinal fluid (CSF) from 37 unmedicated healthy volunteers (mean ± SD = 23.4 ± 7.2 pg/ml). A second lumbar puncture in 11 of these subjects suggested that the CSF GHRF levels were stable over time. High performance liquid chromatography revealed that the CSF immunoreactivity co-eluted with the 1-44NH2 and 1-4ONH2 forms of GHRF. Measurements of GHRF in sequential CSF aliquots revealed no evidence of a rostro-caudal gradient, an observation that is compatible with the hypothesis that GHRF has a long half-life in CSF. A significant negative correlation with body weight was found in the 37 subjects. Levels of CSF GHRF were determined in 24 lithium-treated euthymic bipolar patients, 13 of whom provided a second CSF sample during the unmedicated state. No group differences or effects of lithium were noted.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalPsychiatry Research
Volume22
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Growth Hormone-Releasing Hormone
Cerebrospinal Fluid
Lithium
Spinal Puncture
Radio
Immunoassay
Half-Life
Healthy Volunteers
High Pressure Liquid Chromatography
Body Weight
Observation

Keywords

  • cerebrospinal fluid
  • Growth hormone releasing factor
  • manic-depressive illness

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Growth hormone releasing factor in human cerebrospinal fluid. / Berrettini, Wade H.; Nurnberger, John; Simmons-Alling, Susan.

In: Psychiatry Research, Vol. 22, No. 2, 1987, p. 141-147.

Research output: Contribution to journalArticle

Berrettini, Wade H. ; Nurnberger, John ; Simmons-Alling, Susan. / Growth hormone releasing factor in human cerebrospinal fluid. In: Psychiatry Research. 1987 ; Vol. 22, No. 2. pp. 141-147.
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