Growth hormone releasing factor in human cerebrospinal fluid

Wade H. Berrettini, John I. Nurnberger, Susan Simmons-Alling

Research output: Contribution to journalArticle

9 Scopus citations


Growth hormone releasing factor (GHRF) was determined by radio-immunoassay in cerebrospinal fluid (CSF) from 37 unmedicated healthy volunteers (mean ± SD = 23.4 ± 7.2 pg/ml). A second lumbar puncture in 11 of these subjects suggested that the CSF GHRF levels were stable over time. High performance liquid chromatography revealed that the CSF immunoreactivity co-eluted with the 1-44NH2 and 1-4ONH2 forms of GHRF. Measurements of GHRF in sequential CSF aliquots revealed no evidence of a rostro-caudal gradient, an observation that is compatible with the hypothesis that GHRF has a long half-life in CSF. A significant negative correlation with body weight was found in the 37 subjects. Levels of CSF GHRF were determined in 24 lithium-treated euthymic bipolar patients, 13 of whom provided a second CSF sample during the unmedicated state. No group differences or effects of lithium were noted.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalPsychiatry Research
Issue number2
StatePublished - Oct 1987
Externally publishedYes


  • cerebrospinal fluid
  • Growth hormone releasing factor
  • manic-depressive illness

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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