Growth of a nation part II: Impact of recipient obesity on whole-organ pancreas transplantation

Jonathan A. Fridell, Richard Mangus, Tim Taber, Michelle L. Goble, Martin L. Milgrom, Jason Good, Ryan Vetor, John A. Powelson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Obesity has reached epidemic proportions in the USA. Consequently, there is an increasing number of obese diabetic patients who would otherwise be appropriate candidates for pancreas transplantation (PTx). This is a retrospective study of all PTx performed at Indiana University between 2003 and 2009 (n=308) comparing recipients with body mass index (BMI)<25, 25-29.9, and ≥30kg/m 2 Data included recipient and donor demographics, seven and 90-d graft loss, one-yr pancreas, kidney (for SPK only) and patient survival, causes of graft loss and death, peak amylase and lipase, length of stay, readmissions, complications, HbA1C, and c-peptide. Of the 308 PTx, 100 (32%) were overweight and 42 (14%) were obese. Obese recipients were older and more likely to be men. Donor demographics were similar. There was no difference in seven-d or 90-d graft loss, one-yr pancreas, kidney or patient survival, cause of graft loss or death, 30-d peak amylase or lipase, HbA1C, or C-peptide. The incidence of post-transplant technical, immunological and infectious complications was similar except for an increased incidence of cytomegalovirus infection in the obese group. Two recipients returned to insulin therapy despite normal C-peptide levels. Although technically challenging, PTx can be successful in select obese recipients with similar results compared to normal BMI recipients.

Original languageEnglish
JournalClinical Transplantation
Volume25
Issue number4
DOIs
StatePublished - Jul 2011

Fingerprint

Pancreas Transplantation
Organ Transplantation
Obesity
C-Peptide
Graft Survival
Amylases
Lipase
Transplants
Pancreas
Body Mass Index
Growth
Demography
Tissue Donors
Kidney
Incidence
Cytomegalovirus Infections
Length of Stay
Retrospective Studies
Insulin
Peptides

Keywords

  • Obesity
  • Organ donor
  • Pancreas transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Growth of a nation part II : Impact of recipient obesity on whole-organ pancreas transplantation. / Fridell, Jonathan A.; Mangus, Richard; Taber, Tim; Goble, Michelle L.; Milgrom, Martin L.; Good, Jason; Vetor, Ryan; Powelson, John A.

In: Clinical Transplantation, Vol. 25, No. 4, 07.2011.

Research output: Contribution to journalArticle

Fridell, Jonathan A. ; Mangus, Richard ; Taber, Tim ; Goble, Michelle L. ; Milgrom, Martin L. ; Good, Jason ; Vetor, Ryan ; Powelson, John A. / Growth of a nation part II : Impact of recipient obesity on whole-organ pancreas transplantation. In: Clinical Transplantation. 2011 ; Vol. 25, No. 4.
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