Growth of the lung parenchyma early in life

Juan E. Balinotti, Christina J. Tiller, Conrado J. Llapur, Marcus H. Jones, Risa N. Kimmel, Cathy E. Coates, Barry Katz, James T. Nguyen, Robert Tepper

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Rationale: Early in life, lung growth can occur by alveolarization, an increase in the number of alveoli, as well as expansion. We hypothesized that if lung growth early in life occurred primarily by alveolarization, then the ratio of pulmonary diffusion capacity of carbon monoxide (DLCO) to alveolar volume (VA) would remain constant; however, if lung growth occurred primarily by alveolar expansion, then DLCO/VA would decline with increasing age, as observed in older children and adolescents. Objectives: To evaluate the relationship between alveolar volume and pulmonary diffusion capacity early in life. Methods: In 50 sleeping infants and toddlers, with equal number of males and females between the ages of 3 and 23 months, we measured DLCO and VA using single breath-hold maneuvers at elevated lung volumes. Measurements and Main Results: DLCO and VA increased with increasing age and body length. Males had higher DLCO and VA when adjusted for age, but not when adjusted for length. DLCO increased with VA; there was no gender difference when DLCO was adjusted for V A. The ratio of DLCO/VA remained constant with age and body length. Conclusions: Our results suggest that surface area for diffusion increases proportionally with alveolar volume in the first 2 years of life. Larger DLCO and VA for males than females when adjusted for age, but not when adjusted for length, is primarily related to greater body length in boys. The constant ratio for DLCO/V A in infants and toddlers is consistent with lung growth in this age occurring primarily by the addition of alveoli rather than the expansion of alveoli.

Original languageEnglish
Pages (from-to)134-137
Number of pages4
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume179
Issue number2
DOIs
StatePublished - Jan 15 2009

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Lung
Lung Volume Measurements
Growth
Carbon Monoxide

Keywords

  • Alveolar volume
  • Lung development
  • Pulmonary diffusion capacity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Balinotti, J. E., Tiller, C. J., Llapur, C. J., Jones, M. H., Kimmel, R. N., Coates, C. E., ... Tepper, R. (2009). Growth of the lung parenchyma early in life. American Journal of Respiratory and Critical Care Medicine, 179(2), 134-137. https://doi.org/10.1164/rccm.200808-1224OC

Growth of the lung parenchyma early in life. / Balinotti, Juan E.; Tiller, Christina J.; Llapur, Conrado J.; Jones, Marcus H.; Kimmel, Risa N.; Coates, Cathy E.; Katz, Barry; Nguyen, James T.; Tepper, Robert.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 179, No. 2, 15.01.2009, p. 134-137.

Research output: Contribution to journalArticle

Balinotti, JE, Tiller, CJ, Llapur, CJ, Jones, MH, Kimmel, RN, Coates, CE, Katz, B, Nguyen, JT & Tepper, R 2009, 'Growth of the lung parenchyma early in life', American Journal of Respiratory and Critical Care Medicine, vol. 179, no. 2, pp. 134-137. https://doi.org/10.1164/rccm.200808-1224OC
Balinotti JE, Tiller CJ, Llapur CJ, Jones MH, Kimmel RN, Coates CE et al. Growth of the lung parenchyma early in life. American Journal of Respiratory and Critical Care Medicine. 2009 Jan 15;179(2):134-137. https://doi.org/10.1164/rccm.200808-1224OC
Balinotti, Juan E. ; Tiller, Christina J. ; Llapur, Conrado J. ; Jones, Marcus H. ; Kimmel, Risa N. ; Coates, Cathy E. ; Katz, Barry ; Nguyen, James T. ; Tepper, Robert. / Growth of the lung parenchyma early in life. In: American Journal of Respiratory and Critical Care Medicine. 2009 ; Vol. 179, No. 2. pp. 134-137.
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