Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

Lawrence A. Quilliam, Roya Khosravi‐Far, Shayne Y. Huff, Channing J. Der

Research output: Contribution to journalReview article

185 Scopus citations


Ras proteins function as critical relay switches that regulate diverse signaling pathways between cell surface receptors and the nucleus. Over the past 2‐3 years researchers have identified many components of these pathways that mediate Ras activation and effector function. Among these proteins are several guanine nucleotide exchange factors (GEFs), which are responsible for directly interacting with and activating Ras in response to extracellular stimuli. Analogous GEFs regulate Ras‐related proteins that serve other diverse cellular functions. In particular, a growing family of proteins (Dbl homology proteins) has recently been identified, which may function as GEFs for the Rho family of Ras‐related proteins. This review summarizes our current knowledge of the structure, biochemistry and biology of Ras and Rho family GEFs. Additionally, we describe mechanisms of GEF activation of Ras in signal transduction and address the potential that deregulated GEFs might contribute to malignant transformation through chronic Ras protein activation.

Original languageEnglish (US)
Pages (from-to)395-404
Number of pages10
Issue number5
StatePublished - May 1995

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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