Guillain-Barré syndrome associated with resistant cytomegalovirus infection after face transplantation

M. Alhefzi, M. A. Aycart, E. M. Bueno, M. Kueckelhaus, S. Fischer, R. J. Snook, Asif Sharfuddin, I. Hadad, P. Malla, A. A. Amato, Bohdan Pomahac, F. M. Marty

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A 39-year-old male, who received a facial allograft (cytomegalovirus [CMV] donor-seropositive, recipient-seronegative), developed multidrug-resistant CMV infection despite valganciclovir prophylaxis (900 mg/day) 6 months post transplantation. Lower extremity weakness with upper and lower extremity paresthesias developed progressively 11 months post transplantation, coinciding with immune control of CMV. An axonal form of Guillain-Barré syndrome was diagnosed, based on electrophysiological evidence of a generalized, non-length-dependent, sensorimotor axonal polyneuropathy. Treatment with intravenous immunoglobulin led to complete recovery without recurrence after 6 months.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalTransplant Infectious Disease
Volume18
Issue number2
DOIs
StatePublished - Apr 1 2016

Keywords

  • Cytomegalovirus
  • Face transplantation
  • Guillain-Barré syndrome
  • Peripheral neuropathy
  • Vascularized composite allotransplantation

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

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    Alhefzi, M., Aycart, M. A., Bueno, E. M., Kueckelhaus, M., Fischer, S., Snook, R. J., Sharfuddin, A., Hadad, I., Malla, P., Amato, A. A., Pomahac, B., & Marty, F. M. (2016). Guillain-Barré syndrome associated with resistant cytomegalovirus infection after face transplantation. Transplant Infectious Disease, 18(2), 288-292. https://doi.org/10.1111/tid.12516