Guillain-Barré syndrome associated with resistant cytomegalovirus infection after face transplantation

M. Alhefzi, M. A. Aycart, E. M. Bueno, M. Kueckelhaus, S. Fischer, R. J. Snook, Asif Sharfuddin, I. Hadad, P. Malla, A. A. Amato, Bohdan Pomahac, F. M. Marty

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A 39-year-old male, who received a facial allograft (cytomegalovirus [CMV] donor-seropositive, recipient-seronegative), developed multidrug-resistant CMV infection despite valganciclovir prophylaxis (900 mg/day) 6 months post transplantation. Lower extremity weakness with upper and lower extremity paresthesias developed progressively 11 months post transplantation, coinciding with immune control of CMV. An axonal form of Guillain-Barré syndrome was diagnosed, based on electrophysiological evidence of a generalized, non-length-dependent, sensorimotor axonal polyneuropathy. Treatment with intravenous immunoglobulin led to complete recovery without recurrence after 6 months.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalTransplant Infectious Disease
Volume18
Issue number2
DOIs
StatePublished - Apr 1 2016

Fingerprint

Facial Transplantation
Cytomegalovirus Infections
Cytomegalovirus
Lower Extremity
Transplantation
Polyneuropathies
Paresthesia
Intravenous Immunoglobulins
Allografts
Recurrence
Therapeutics

Keywords

  • Cytomegalovirus
  • Face transplantation
  • Guillain-Barré syndrome
  • Peripheral neuropathy
  • Vascularized composite allotransplantation

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Alhefzi, M., Aycart, M. A., Bueno, E. M., Kueckelhaus, M., Fischer, S., Snook, R. J., ... Marty, F. M. (2016). Guillain-Barré syndrome associated with resistant cytomegalovirus infection after face transplantation. Transplant Infectious Disease, 18(2), 288-292. https://doi.org/10.1111/tid.12516

Guillain-Barré syndrome associated with resistant cytomegalovirus infection after face transplantation. / Alhefzi, M.; Aycart, M. A.; Bueno, E. M.; Kueckelhaus, M.; Fischer, S.; Snook, R. J.; Sharfuddin, Asif; Hadad, I.; Malla, P.; Amato, A. A.; Pomahac, Bohdan; Marty, F. M.

In: Transplant Infectious Disease, Vol. 18, No. 2, 01.04.2016, p. 288-292.

Research output: Contribution to journalArticle

Alhefzi, M, Aycart, MA, Bueno, EM, Kueckelhaus, M, Fischer, S, Snook, RJ, Sharfuddin, A, Hadad, I, Malla, P, Amato, AA, Pomahac, B & Marty, FM 2016, 'Guillain-Barré syndrome associated with resistant cytomegalovirus infection after face transplantation', Transplant Infectious Disease, vol. 18, no. 2, pp. 288-292. https://doi.org/10.1111/tid.12516
Alhefzi, M. ; Aycart, M. A. ; Bueno, E. M. ; Kueckelhaus, M. ; Fischer, S. ; Snook, R. J. ; Sharfuddin, Asif ; Hadad, I. ; Malla, P. ; Amato, A. A. ; Pomahac, Bohdan ; Marty, F. M. / Guillain-Barré syndrome associated with resistant cytomegalovirus infection after face transplantation. In: Transplant Infectious Disease. 2016 ; Vol. 18, No. 2. pp. 288-292.
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