Haemophilus ducreyi: Chancroid

Tricia L. Humphreys, Diane Janowicz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Haemophilus ducreyi is a small, Gram-negative coccobacillus that causes the genital ulcer disease known as chancroid. Chancroid increases the risk for transmission and acquisition of HIV-1. The prevalence of the disease is unknown due to syndromic management of genital ulcer disease, but outbreaks continue to be reported in developing countries and in populations with high numbers of sexual partners. Patients with chancroid seek medical care several weeks after acquiring the infection when they become symptomatic and complain of painful genital ulcers that are often associated with suppurative inguinal lymphadenopathy. Research has focused on identifying virulence factors, the most notable of which play roles in adherence to extracellular matrix components and resistance to both phagocytosis and complement-mediated killing. Single-dose antibiotic therapy with macrolides or third-generation cephalosporins or with fluoroquinolones remains effective for the treatment of chancroid, but patients remain susceptible to reinfection as protective immunity does not develop.

Original languageEnglish (US)
Title of host publicationMolecular Medical Microbiology: Second Edition
PublisherElsevier Ltd
Pages1437-1447
Number of pages11
Volume3
ISBN (Print)9780123971692, 9780126775303
DOIs
StatePublished - Nov 26 2014

Fingerprint

Haemophilus ducreyi
Chancroid
Ulcer
Fluoroquinolones
Macrolides
Virulence Factors
Cephalosporins
Health care
Developing countries
Groin
Sexual Partners
Phagocytosis
Developing Countries
Anti-Bacterial Agents
Disease Outbreaks
Extracellular Matrix
HIV-1
Immunity
Therapeutics
Infection

Keywords

  • Chancroid
  • Genital ulcer disease
  • Haemophilus ducreyi
  • Sexually transmitted infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Humphreys, T. L., & Janowicz, D. (2014). Haemophilus ducreyi: Chancroid. In Molecular Medical Microbiology: Second Edition (Vol. 3, pp. 1437-1447). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-397169-2.00080-9

Haemophilus ducreyi : Chancroid. / Humphreys, Tricia L.; Janowicz, Diane.

Molecular Medical Microbiology: Second Edition. Vol. 3 Elsevier Ltd, 2014. p. 1437-1447.

Research output: Chapter in Book/Report/Conference proceedingChapter

Humphreys, TL & Janowicz, D 2014, Haemophilus ducreyi: Chancroid. in Molecular Medical Microbiology: Second Edition. vol. 3, Elsevier Ltd, pp. 1437-1447. https://doi.org/10.1016/B978-0-12-397169-2.00080-9
Humphreys TL, Janowicz D. Haemophilus ducreyi: Chancroid. In Molecular Medical Microbiology: Second Edition. Vol. 3. Elsevier Ltd. 2014. p. 1437-1447 https://doi.org/10.1016/B978-0-12-397169-2.00080-9
Humphreys, Tricia L. ; Janowicz, Diane. / Haemophilus ducreyi : Chancroid. Molecular Medical Microbiology: Second Edition. Vol. 3 Elsevier Ltd, 2014. pp. 1437-1447
@inbook{3f1aac61e9cf4fbfa92c9d75b8ebf601,
title = "Haemophilus ducreyi: Chancroid",
abstract = "Haemophilus ducreyi is a small, Gram-negative coccobacillus that causes the genital ulcer disease known as chancroid. Chancroid increases the risk for transmission and acquisition of HIV-1. The prevalence of the disease is unknown due to syndromic management of genital ulcer disease, but outbreaks continue to be reported in developing countries and in populations with high numbers of sexual partners. Patients with chancroid seek medical care several weeks after acquiring the infection when they become symptomatic and complain of painful genital ulcers that are often associated with suppurative inguinal lymphadenopathy. Research has focused on identifying virulence factors, the most notable of which play roles in adherence to extracellular matrix components and resistance to both phagocytosis and complement-mediated killing. Single-dose antibiotic therapy with macrolides or third-generation cephalosporins or with fluoroquinolones remains effective for the treatment of chancroid, but patients remain susceptible to reinfection as protective immunity does not develop.",
keywords = "Chancroid, Genital ulcer disease, Haemophilus ducreyi, Sexually transmitted infection",
author = "Humphreys, {Tricia L.} and Diane Janowicz",
year = "2014",
month = "11",
day = "26",
doi = "10.1016/B978-0-12-397169-2.00080-9",
language = "English (US)",
isbn = "9780123971692",
volume = "3",
pages = "1437--1447",
booktitle = "Molecular Medical Microbiology: Second Edition",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Haemophilus ducreyi

T2 - Chancroid

AU - Humphreys, Tricia L.

AU - Janowicz, Diane

PY - 2014/11/26

Y1 - 2014/11/26

N2 - Haemophilus ducreyi is a small, Gram-negative coccobacillus that causes the genital ulcer disease known as chancroid. Chancroid increases the risk for transmission and acquisition of HIV-1. The prevalence of the disease is unknown due to syndromic management of genital ulcer disease, but outbreaks continue to be reported in developing countries and in populations with high numbers of sexual partners. Patients with chancroid seek medical care several weeks after acquiring the infection when they become symptomatic and complain of painful genital ulcers that are often associated with suppurative inguinal lymphadenopathy. Research has focused on identifying virulence factors, the most notable of which play roles in adherence to extracellular matrix components and resistance to both phagocytosis and complement-mediated killing. Single-dose antibiotic therapy with macrolides or third-generation cephalosporins or with fluoroquinolones remains effective for the treatment of chancroid, but patients remain susceptible to reinfection as protective immunity does not develop.

AB - Haemophilus ducreyi is a small, Gram-negative coccobacillus that causes the genital ulcer disease known as chancroid. Chancroid increases the risk for transmission and acquisition of HIV-1. The prevalence of the disease is unknown due to syndromic management of genital ulcer disease, but outbreaks continue to be reported in developing countries and in populations with high numbers of sexual partners. Patients with chancroid seek medical care several weeks after acquiring the infection when they become symptomatic and complain of painful genital ulcers that are often associated with suppurative inguinal lymphadenopathy. Research has focused on identifying virulence factors, the most notable of which play roles in adherence to extracellular matrix components and resistance to both phagocytosis and complement-mediated killing. Single-dose antibiotic therapy with macrolides or third-generation cephalosporins or with fluoroquinolones remains effective for the treatment of chancroid, but patients remain susceptible to reinfection as protective immunity does not develop.

KW - Chancroid

KW - Genital ulcer disease

KW - Haemophilus ducreyi

KW - Sexually transmitted infection

UR - http://www.scopus.com/inward/record.url?scp=84961137277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961137277&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-397169-2.00080-9

DO - 10.1016/B978-0-12-397169-2.00080-9

M3 - Chapter

AN - SCOPUS:84961137277

SN - 9780123971692

SN - 9780126775303

VL - 3

SP - 1437

EP - 1447

BT - Molecular Medical Microbiology: Second Edition

PB - Elsevier Ltd

ER -