Abstract
Haemophilus ducreyi is a small, Gram-negative coccobacillus that causes the genital ulcer disease known as chancroid. Chancroid increases the risk for transmission and acquisition of HIV-1. The prevalence of the disease is unknown due to syndromic management of genital ulcer disease, but outbreaks continue to be reported in developing countries and in populations with high numbers of sexual partners. Patients with chancroid seek medical care several weeks after acquiring the infection when they become symptomatic and complain of painful genital ulcers that are often associated with suppurative inguinal lymphadenopathy. Research has focused on identifying virulence factors, the most notable of which play roles in adherence to extracellular matrix components and resistance to both phagocytosis and complement-mediated killing. Single-dose antibiotic therapy with macrolides or third-generation cephalosporins or with fluoroquinolones remains effective for the treatment of chancroid, but patients remain susceptible to reinfection as protective immunity does not develop.
| Original language | English (US) |
|---|---|
| Title of host publication | Molecular Medical Microbiology: Second Edition |
| Publisher | Elsevier Ltd |
| Pages | 1437-1447 |
| Number of pages | 11 |
| Volume | 3 |
| ISBN (Print) | 9780123971692, 9780126775303 |
| DOIs | |
| State | Published - Nov 26 2014 |
Fingerprint
Keywords
- Chancroid
- Genital ulcer disease
- Haemophilus ducreyi
- Sexually transmitted infection
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Haemophilus ducreyi : Chancroid. / Humphreys, Tricia L.; Janowicz, Diane.
Molecular Medical Microbiology: Second Edition. Vol. 3 Elsevier Ltd, 2014. p. 1437-1447.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Haemophilus ducreyi
T2 - Chancroid
AU - Humphreys, Tricia L.
AU - Janowicz, Diane
PY - 2014/11/26
Y1 - 2014/11/26
N2 - Haemophilus ducreyi is a small, Gram-negative coccobacillus that causes the genital ulcer disease known as chancroid. Chancroid increases the risk for transmission and acquisition of HIV-1. The prevalence of the disease is unknown due to syndromic management of genital ulcer disease, but outbreaks continue to be reported in developing countries and in populations with high numbers of sexual partners. Patients with chancroid seek medical care several weeks after acquiring the infection when they become symptomatic and complain of painful genital ulcers that are often associated with suppurative inguinal lymphadenopathy. Research has focused on identifying virulence factors, the most notable of which play roles in adherence to extracellular matrix components and resistance to both phagocytosis and complement-mediated killing. Single-dose antibiotic therapy with macrolides or third-generation cephalosporins or with fluoroquinolones remains effective for the treatment of chancroid, but patients remain susceptible to reinfection as protective immunity does not develop.
AB - Haemophilus ducreyi is a small, Gram-negative coccobacillus that causes the genital ulcer disease known as chancroid. Chancroid increases the risk for transmission and acquisition of HIV-1. The prevalence of the disease is unknown due to syndromic management of genital ulcer disease, but outbreaks continue to be reported in developing countries and in populations with high numbers of sexual partners. Patients with chancroid seek medical care several weeks after acquiring the infection when they become symptomatic and complain of painful genital ulcers that are often associated with suppurative inguinal lymphadenopathy. Research has focused on identifying virulence factors, the most notable of which play roles in adherence to extracellular matrix components and resistance to both phagocytosis and complement-mediated killing. Single-dose antibiotic therapy with macrolides or third-generation cephalosporins or with fluoroquinolones remains effective for the treatment of chancroid, but patients remain susceptible to reinfection as protective immunity does not develop.
KW - Chancroid
KW - Genital ulcer disease
KW - Haemophilus ducreyi
KW - Sexually transmitted infection
UR - http://www.scopus.com/inward/record.url?scp=84961137277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961137277&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-397169-2.00080-9
DO - 10.1016/B978-0-12-397169-2.00080-9
M3 - Chapter
AN - SCOPUS:84961137277
SN - 9780123971692
SN - 9780126775303
VL - 3
SP - 1437
EP - 1447
BT - Molecular Medical Microbiology: Second Edition
PB - Elsevier Ltd
ER -