Haemophilus ducreyi is susceptible to protegrin

Kate Fortney, Patricia A. Totten, Robert I. Lehrer, Stanley Spinola

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Protegrins, potent antimicrobial peptides found in porcine leukocytes, have activity against the sexually transmitted pathogens Neisseria gonorrhoeae, Chlamydia trachomatis, and human immunodeficiency virus type 1. We tested synthetic protegrin 1 (PG-1) for activity against nine isolates of Haemophilus ducreyi, the etiologic agent of chancroid. The test organisms included CIP 542 (the type strain), 35000HP (a human-passaged variant of 35000), 35000HP-RSM2 (an isogenic D-glycero-D-manno-heptosyltransferase mutant of 35000HP), and six clinical isolates. The isolates were epidemiologically unrelated, represented three HindIII ribotypes, and had varying antimicrobial resistance patterns. In bactericidal assays, five isolates were rapidly killed by synthetic PG-1. In radial diffusion assays, all nine isolates were exquisitely sensitive to PG-1. These data highlight the potential of protegrins for development as topical agents to prevent many sexually transmitted diseases, including chancroid.

Original languageEnglish
Pages (from-to)2690-2693
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume42
Issue number10
StatePublished - Oct 1998

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Haemophilus ducreyi
Chancroid
Ribotyping
Neisseria gonorrhoeae
Chlamydia trachomatis
Sexually Transmitted Diseases
HIV-1
Leukocytes
Swine
Peptides
protegrin-1

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Fortney, K., Totten, P. A., Lehrer, R. I., & Spinola, S. (1998). Haemophilus ducreyi is susceptible to protegrin. Antimicrobial Agents and Chemotherapy, 42(10), 2690-2693.

Haemophilus ducreyi is susceptible to protegrin. / Fortney, Kate; Totten, Patricia A.; Lehrer, Robert I.; Spinola, Stanley.

In: Antimicrobial Agents and Chemotherapy, Vol. 42, No. 10, 10.1998, p. 2690-2693.

Research output: Contribution to journalArticle

Fortney, K, Totten, PA, Lehrer, RI & Spinola, S 1998, 'Haemophilus ducreyi is susceptible to protegrin', Antimicrobial Agents and Chemotherapy, vol. 42, no. 10, pp. 2690-2693.
Fortney, Kate ; Totten, Patricia A. ; Lehrer, Robert I. ; Spinola, Stanley. / Haemophilus ducreyi is susceptible to protegrin. In: Antimicrobial Agents and Chemotherapy. 1998 ; Vol. 42, No. 10. pp. 2690-2693.
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