Haemopoietic stem/progenitor cell transplant in Fanconi anaemia using HLA‐matched sibling umbilical cord blood cells

Mudra Kohli‐Kumar, Nasorullah T. Shahidi, Hal E. Broxmeyer, Margaret Masterson, Cynthia Delaat, James Sambrano, Christopher Morris, Arleen D. Auerbach, Richard E. Harris

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Abstract

Summary There have only been a few reports documenting the use of umbilical cord blood as a source of stem cells for haemopoietic reconstitution. We report our experience with a child with Fanconi anaemia (FA) who underwent a stem cell transplant using umbilical cord blood cells from his HLA matched sibling. Although the engraftment was somewhat slow, it was complete and comparable to other transplants performed in FA patients using HLA matched sibling marrow. There was no graft‐versus‐host disease. The post‐transplant period was uncomplicated and, at a follow‐up of 36 months, this child is well with normal blood counts and immune function.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalBritish journal of haematology
Volume85
Issue number2
DOIs
StatePublished - Oct 1993

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ASJC Scopus subject areas

  • Hematology

Cite this

Kohli‐Kumar, M., Shahidi, N. T., Broxmeyer, H. E., Masterson, M., Delaat, C., Sambrano, J., Morris, C., Auerbach, A. D., & Harris, R. E. (1993). Haemopoietic stem/progenitor cell transplant in Fanconi anaemia using HLA‐matched sibling umbilical cord blood cells. British journal of haematology, 85(2), 419-422. https://doi.org/10.1111/j.1365-2141.1993.tb03192.x