Haemorrhagic thiamine deficient encephalopathy following prolonged parenteral nutrition

A. O. Vortmeyer, C. Nagel, R. Laas

Research output: Contribution to journalArticle

29 Scopus citations


Neuropathological examination of three patients who were maintained on parenteral nutrition without substitution of thiamine demonstrated an acute haemorrhagic encephalopathy. The lesions differed substantially from the classic features of thiamine deficient encephalopathy regarding the histopathological alterations and the topographical distribution. The extreme rapidity of thiamine deprivation may have been responsible for the abrupt clinical onset of the disease and the intensity of the morphological alterations.

Original languageEnglish (US)
Pages (from-to)826-829
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number9
StatePublished - 1992

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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