Hair cell damage and recovery following chronic application of kanamycin in the chick cochlea

Eri Hashino, Yasuo Tanaka, Masahiro Sokabe

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Three-day old chicks were given kanamycin at a dose of 200 mg/kg/day for 10 days and their cochleae were processed for scanning electron microscopy at 1, 3, 7 and 14 days following the last injection. Both hair cells and supporting cells were damaged by kanamycin in the basal 35% of the basilar papilla. By 14 days post-treatment, however, most of the damaged region had been replaced with regenerating hair cells and supporting cells. The base-to-apex gradient of morphological development along the cochlea was observed in the process of regeneration. Kinocilium and microvilli were observed on the apical surfaces of the regenerating hair cells.

Original languageEnglish (US)
Pages (from-to)356-368
Number of pages13
JournalHearing Research
Volume52
Issue number2
DOIs
StatePublished - Apr 1991

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Keywords

  • Chick
  • Hair cell
  • Kanamycin
  • Ototoxicity
  • Regeneration

ASJC Scopus subject areas

  • Sensory Systems

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