Haloperidol impairs learning and error-related negativity in humans

Patrick J. Zirnheld, Christine A. Carroll, Paul D. Kieffaber, Brian O'Donnell, Anantha Shekhar, William P. Hetrick

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Humans are able to monitor their actions for behavioral conflicts and performance errors. Growing evidence suggests that the error-related negativity (ERN) of the event-related cortical brain potential (ERP) may index the functioning of this response monitoring system and that the ERN may depend on dopaminergic mechanisms. We examined the role of dopamine in ERN and behavioral indices of learning by administering either 3 mg of the dopamine antagonist (DA) haloperidol (n = 17); 25 mg of diphenhydramine (n = 16), which has a similar CNS profile but without DA properties; or placebo (n = 18) in a randomized, double-blind manner to healthy volunteers. Three hours after drug administration, participants performed a go/no-go Continuous Performance Task, the Eriksen Flanker Task, and a learning-dependent Time Estimation Task. Haloperidol significantly attenuated ERN amplitudes recorded during the flanker task, impaired learning of time intervals, and tended to cause more errors of commission, compared to placebo, which did not significantly differ from diphenhydramine. Drugs had no significant effects on the stimulus-locked P1 and N2 ERPs or on behavioral response latencies, but tended to affect post-error reaction time (RT) latencies in opposite ways (haloperidol decreased and diphenhydramine increased RTs). These findings support the hypothesis that the DA system is involved in learning and the generation of the ERN.

Original languageEnglish
Pages (from-to)1098-1112
Number of pages15
JournalJournal of Cognitive Neuroscience
Volume16
Issue number6
DOIs
StatePublished - Jul 2004

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Haloperidol
Diphenhydramine
Dopamine Antagonists
Learning
Reaction Time
Placebos
Task Performance and Analysis
Pharmaceutical Preparations
Dopamine
Healthy Volunteers
Brain

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

Haloperidol impairs learning and error-related negativity in humans. / Zirnheld, Patrick J.; Carroll, Christine A.; Kieffaber, Paul D.; O'Donnell, Brian; Shekhar, Anantha; Hetrick, William P.

In: Journal of Cognitive Neuroscience, Vol. 16, No. 6, 07.2004, p. 1098-1112.

Research output: Contribution to journalArticle

Zirnheld, Patrick J. ; Carroll, Christine A. ; Kieffaber, Paul D. ; O'Donnell, Brian ; Shekhar, Anantha ; Hetrick, William P. / Haloperidol impairs learning and error-related negativity in humans. In: Journal of Cognitive Neuroscience. 2004 ; Vol. 16, No. 6. pp. 1098-1112.
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