Heart-brain interactions in cardiac arrhythmias

Role of the autonomic nervous system

Douglas P. Zipes

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The autonomic nervous system plays an important role in the genesis of ventricular arrhythmias and sudden cardiac death. Evidence is substantial for a neural component in sudden cardiac death. Sympathetic nerve sprouting and regional myocardial hyperinnervation following myocardial injury promote cardiac arrhythmia and sudden cardiac death through several potential mechanisms. Modulating autonomic tone is a potential method to reduce the risk of ventricular arrhythmias. Thoracic spinal cord stimulation is showing promise as a treatment for refractory angina. In addition, spinal cord stimulation has protected against ventricular tachycardia/ventricular fibrillation in animal models of postinfarction heart failure.

Original languageEnglish
Pages (from-to)94-96
Number of pages3
JournalCleveland Clinic Journal of Medicine
Volume75
Issue numberSUPPL.2
StatePublished - 2008

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Autonomic Nervous System
Sudden Cardiac Death
Spinal Cord Stimulation
Cardiac Arrhythmias
Brain
Ventricular Fibrillation
Ventricular Tachycardia
Thorax
Animal Models
Heart Failure
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Heart-brain interactions in cardiac arrhythmias : Role of the autonomic nervous system. / Zipes, Douglas P.

In: Cleveland Clinic Journal of Medicine, Vol. 75, No. SUPPL.2, 2008, p. 94-96.

Research output: Contribution to journalArticle

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