Heart Failure in Pediatric Patients with Congenital Heart Disease

Robert B. Hinton, Stephanie Ware

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and secondary causes and shared pathways of disease progression, correlating with substantial mortality, morbidity, and cost. HF in children is most commonly attributable to coexistent congenital heart disease, with different risks depending on the specific type of malformation. Current management and therapy for HF in children are extrapolated from treatment approaches in adults. This review discusses the causes, epidemiology, and manifestations of HF in children with congenital heart disease and presents the clinical, genetic, and molecular characteristics that are similar or distinct from adult HF. The objective of this review is to provide a framework for understanding rapidly increasing genetic and molecular information in the challenging context of detailed phenotyping. We review clinical and translational research studies of HF in congenital heart disease including at the genome, transcriptome, and epigenetic levels. Unresolved issues and directions for future study are presented.

Original languageEnglish (US)
Pages (from-to)978-994
Number of pages17
JournalCirculation Research
Volume120
Issue number6
DOIs
StatePublished - Mar 17 2017

Fingerprint

Heart Diseases
Heart Failure
Pediatrics
Molecular Biology
Translational Medical Research
Transcriptome
Epigenomics
Disease Progression
Epidemiology
Genome
Morbidity
Costs and Cost Analysis
Mortality
Therapeutics

Keywords

  • cardiovascular malformation
  • genetics
  • mutation
  • single ventricle
  • stem cell
  • ventricular dysfunction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Heart Failure in Pediatric Patients with Congenital Heart Disease. / Hinton, Robert B.; Ware, Stephanie.

In: Circulation Research, Vol. 120, No. 6, 17.03.2017, p. 978-994.

Research output: Contribution to journalReview article

@article{f39aee5a83e8469b9eb9f74d94d24c50,
title = "Heart Failure in Pediatric Patients with Congenital Heart Disease",
abstract = "Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and secondary causes and shared pathways of disease progression, correlating with substantial mortality, morbidity, and cost. HF in children is most commonly attributable to coexistent congenital heart disease, with different risks depending on the specific type of malformation. Current management and therapy for HF in children are extrapolated from treatment approaches in adults. This review discusses the causes, epidemiology, and manifestations of HF in children with congenital heart disease and presents the clinical, genetic, and molecular characteristics that are similar or distinct from adult HF. The objective of this review is to provide a framework for understanding rapidly increasing genetic and molecular information in the challenging context of detailed phenotyping. We review clinical and translational research studies of HF in congenital heart disease including at the genome, transcriptome, and epigenetic levels. Unresolved issues and directions for future study are presented.",
keywords = "cardiovascular malformation, genetics, mutation, single ventricle, stem cell, ventricular dysfunction",
author = "Hinton, {Robert B.} and Stephanie Ware",
year = "2017",
month = "3",
day = "17",
doi = "10.1161/CIRCRESAHA.116.308996",
language = "English (US)",
volume = "120",
pages = "978--994",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Heart Failure in Pediatric Patients with Congenital Heart Disease

AU - Hinton, Robert B.

AU - Ware, Stephanie

PY - 2017/3/17

Y1 - 2017/3/17

N2 - Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and secondary causes and shared pathways of disease progression, correlating with substantial mortality, morbidity, and cost. HF in children is most commonly attributable to coexistent congenital heart disease, with different risks depending on the specific type of malformation. Current management and therapy for HF in children are extrapolated from treatment approaches in adults. This review discusses the causes, epidemiology, and manifestations of HF in children with congenital heart disease and presents the clinical, genetic, and molecular characteristics that are similar or distinct from adult HF. The objective of this review is to provide a framework for understanding rapidly increasing genetic and molecular information in the challenging context of detailed phenotyping. We review clinical and translational research studies of HF in congenital heart disease including at the genome, transcriptome, and epigenetic levels. Unresolved issues and directions for future study are presented.

AB - Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and secondary causes and shared pathways of disease progression, correlating with substantial mortality, morbidity, and cost. HF in children is most commonly attributable to coexistent congenital heart disease, with different risks depending on the specific type of malformation. Current management and therapy for HF in children are extrapolated from treatment approaches in adults. This review discusses the causes, epidemiology, and manifestations of HF in children with congenital heart disease and presents the clinical, genetic, and molecular characteristics that are similar or distinct from adult HF. The objective of this review is to provide a framework for understanding rapidly increasing genetic and molecular information in the challenging context of detailed phenotyping. We review clinical and translational research studies of HF in congenital heart disease including at the genome, transcriptome, and epigenetic levels. Unresolved issues and directions for future study are presented.

KW - cardiovascular malformation

KW - genetics

KW - mutation

KW - single ventricle

KW - stem cell

KW - ventricular dysfunction

UR - http://www.scopus.com/inward/record.url?scp=85015441225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015441225&partnerID=8YFLogxK

U2 - 10.1161/CIRCRESAHA.116.308996

DO - 10.1161/CIRCRESAHA.116.308996

M3 - Review article

VL - 120

SP - 978

EP - 994

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 6

ER -