Heart Failure in Pediatric Patients with Congenital Heart Disease

Robert B. Hinton, Stephanie M. Ware

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and secondary causes and shared pathways of disease progression, correlating with substantial mortality, morbidity, and cost. HF in children is most commonly attributable to coexistent congenital heart disease, with different risks depending on the specific type of malformation. Current management and therapy for HF in children are extrapolated from treatment approaches in adults. This review discusses the causes, epidemiology, and manifestations of HF in children with congenital heart disease and presents the clinical, genetic, and molecular characteristics that are similar or distinct from adult HF. The objective of this review is to provide a framework for understanding rapidly increasing genetic and molecular information in the challenging context of detailed phenotyping. We review clinical and translational research studies of HF in congenital heart disease including at the genome, transcriptome, and epigenetic levels. Unresolved issues and directions for future study are presented.

Original languageEnglish (US)
Pages (from-to)978-994
Number of pages17
JournalCirculation research
Volume120
Issue number6
DOIs
StatePublished - Mar 17 2017

Keywords

  • cardiovascular malformation
  • genetics
  • mutation
  • single ventricle
  • stem cell
  • ventricular dysfunction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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