Heart rate and motor-activating effects of orally self-administered ethanol in alcohol-preferring (P) rats

Richard Bell, Zachary Rodd, Amy A. Webster, Lawrence Lumeng, Ting Kai Li, William J. McBride, James M. Murphy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Autonomic and behavioral arousals often accompany reinforcement. Additionally, contextual cues associated with alcohol consumption elicit increases in heart rate in alcoholics. This study examined changes in heart rate (HR) and motor activity before and during limited-access to ethanol, saccharin, or water in adult male alcohol-preferring (P) rats. Methods: Adult male P rats were implanted with radiotelemetric transmitters to measure HR and motor activity. The experiment involved placing the animals in a test chamber for a 90-min pretest period, with water available. Thereafter, the animals were given a 90-min test session with access to one of three test solutions: water, 0.0125% saccharin, or 15% (v/v) ethanol (EtOH). After a week of habituation (water served as the test solution for all three groups), the animals were given their respective test solution for 3 weeks. Results: Analyses of HR revealed that the saccharin and EtOH groups had significantly higher HR than the water group during the pretest period of the third test week. Both the saccharin and EtOH groups had significantly higher HR than the water group during the test period of all three test weeks. Analyses of motor activity revealed that the EtOH group displayed higher motor activity than the water and saccharin groups during the pretest period of the third test week. Conclusions: The data indicate that oral self-administration of EtOH enhances behavioral and autonomic activation, compared with saccharin or water, in adult male P rats and support previous observations that changes in HR can be used as an index of reinforcement. Additionally, it seems that the behavioral and autonomic activation elicited by EtOH self-administration can be conditioned to the environment in which EtOH was self-administered. These findings parallel reports on cued reactivity (behavioral and autonomic activation) in alcoholics exposed to alcohol-associated stimuli.

Original languageEnglish
Pages (from-to)1162-1170
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Volume26
Issue number8
StatePublished - Aug 2002

Fingerprint

Saccharin
Rats
Ethanol
Heart Rate
Alcohols
Water
Motor Activity
Animals
Self Administration
Chemical activation
Alcoholics
Reinforcement
Arousal
Alcohol Drinking
Cues
Oral Administration
Transmitters

Keywords

  • Alcohol
  • Alcohol-Preferring Rats
  • Heart Rate
  • Motor Activity
  • Stimulation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Heart rate and motor-activating effects of orally self-administered ethanol in alcohol-preferring (P) rats. / Bell, Richard; Rodd, Zachary; Webster, Amy A.; Lumeng, Lawrence; Li, Ting Kai; McBride, William J.; Murphy, James M.

In: Alcoholism: Clinical and Experimental Research, Vol. 26, No. 8, 08.2002, p. 1162-1170.

Research output: Contribution to journalArticle

Bell, Richard ; Rodd, Zachary ; Webster, Amy A. ; Lumeng, Lawrence ; Li, Ting Kai ; McBride, William J. ; Murphy, James M. / Heart rate and motor-activating effects of orally self-administered ethanol in alcohol-preferring (P) rats. In: Alcoholism: Clinical and Experimental Research. 2002 ; Vol. 26, No. 8. pp. 1162-1170.
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AU - Rodd, Zachary

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AU - McBride, William J.

AU - Murphy, James M.

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N2 - Background: Autonomic and behavioral arousals often accompany reinforcement. Additionally, contextual cues associated with alcohol consumption elicit increases in heart rate in alcoholics. This study examined changes in heart rate (HR) and motor activity before and during limited-access to ethanol, saccharin, or water in adult male alcohol-preferring (P) rats. Methods: Adult male P rats were implanted with radiotelemetric transmitters to measure HR and motor activity. The experiment involved placing the animals in a test chamber for a 90-min pretest period, with water available. Thereafter, the animals were given a 90-min test session with access to one of three test solutions: water, 0.0125% saccharin, or 15% (v/v) ethanol (EtOH). After a week of habituation (water served as the test solution for all three groups), the animals were given their respective test solution for 3 weeks. Results: Analyses of HR revealed that the saccharin and EtOH groups had significantly higher HR than the water group during the pretest period of the third test week. Both the saccharin and EtOH groups had significantly higher HR than the water group during the test period of all three test weeks. Analyses of motor activity revealed that the EtOH group displayed higher motor activity than the water and saccharin groups during the pretest period of the third test week. Conclusions: The data indicate that oral self-administration of EtOH enhances behavioral and autonomic activation, compared with saccharin or water, in adult male P rats and support previous observations that changes in HR can be used as an index of reinforcement. Additionally, it seems that the behavioral and autonomic activation elicited by EtOH self-administration can be conditioned to the environment in which EtOH was self-administered. These findings parallel reports on cued reactivity (behavioral and autonomic activation) in alcoholics exposed to alcohol-associated stimuli.

AB - Background: Autonomic and behavioral arousals often accompany reinforcement. Additionally, contextual cues associated with alcohol consumption elicit increases in heart rate in alcoholics. This study examined changes in heart rate (HR) and motor activity before and during limited-access to ethanol, saccharin, or water in adult male alcohol-preferring (P) rats. Methods: Adult male P rats were implanted with radiotelemetric transmitters to measure HR and motor activity. The experiment involved placing the animals in a test chamber for a 90-min pretest period, with water available. Thereafter, the animals were given a 90-min test session with access to one of three test solutions: water, 0.0125% saccharin, or 15% (v/v) ethanol (EtOH). After a week of habituation (water served as the test solution for all three groups), the animals were given their respective test solution for 3 weeks. Results: Analyses of HR revealed that the saccharin and EtOH groups had significantly higher HR than the water group during the pretest period of the third test week. Both the saccharin and EtOH groups had significantly higher HR than the water group during the test period of all three test weeks. Analyses of motor activity revealed that the EtOH group displayed higher motor activity than the water and saccharin groups during the pretest period of the third test week. Conclusions: The data indicate that oral self-administration of EtOH enhances behavioral and autonomic activation, compared with saccharin or water, in adult male P rats and support previous observations that changes in HR can be used as an index of reinforcement. Additionally, it seems that the behavioral and autonomic activation elicited by EtOH self-administration can be conditioned to the environment in which EtOH was self-administered. These findings parallel reports on cued reactivity (behavioral and autonomic activation) in alcoholics exposed to alcohol-associated stimuli.

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