Heart rate control in normal and aborted-SIDS infants

S. M. Pincus, Theodore Cummins, G. G. Haddad

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

Approximate entropy (ApEn), a mathematical formula quantifying regularity in data, was applied to heart rate data from normal and aborted-sudden infant death syndrome (SIDS) infants. We distinguished quiet from rapid-eye-movement (REM) sleep via the following three criteria, refining the notion of REM as more 'variable': 1) REM sleep has greater overall variability (0.0374 ± 0.0138 vs. 0.0205 ± 0.0090 s, P < 0.005); 2) REM sleep is less stationary (StatAv = 0.742 ± 0.110) than quiet sleep (StatAv = 0.599 ± 0.159, P < 0.03); 3) after normalization to overall variability, REM sleep is more regular (ApEn(sub) = 1.224 ± 0.092) than quiet sleep (ApEn(sub) = 1.448 ± 0.071, P < 0.0001). Fifty percent of aborted-SIDS infants showed greater ApEn instability across quiet sleep than any normal infant exhibited, suggesting that autonomic regulation of heart rate occasionally becomes abnormal in a high-risk subject. There was an association between low ApEn values and aborted-SIDS events; 5 of 14 aborted-SIDS infants had at least one quiet sleep epoch with an ApEn value below the minimum of 45 normal-infant ApEn values.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume264
Issue number3 33-3
StatePublished - 1993
Externally publishedYes

Fingerprint

Sudden Infant Death
Entropy
Sleep
Heart Rate
REM Sleep

Keywords

  • approximate entropy
  • nonstationary
  • probabilistic phenomenon
  • quiet sleep
  • rapid eye movement
  • variability

ASJC Scopus subject areas

  • Physiology

Cite this

Heart rate control in normal and aborted-SIDS infants. / Pincus, S. M.; Cummins, Theodore; Haddad, G. G.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 264, No. 3 33-3, 1993.

Research output: Contribution to journalArticle

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