Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer

Costantine Albany, Noah M. Hahn

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Defects within apoptotic pathways have been implicated in prostate cancer (PCa) tumorigenesis, metastatic progression and treatment resistance. A hallmark of cancers is the ability to derail apoptosis by inhibiting the apoptotic signal, reducing the expression of apoptotic proteins and/or amplifying survival signals through increased production of antiapoptotic molecule. This review describes associations between heat shock proteins (HSPs) and the human androgen receptor (AR), the role of HSPs and other stress-induced proteins in PCa development and emerging strategies in targeting these protective proteins to treat PCa.

Original languageEnglish (US)
Pages (from-to)359-363
Number of pages5
JournalAsian Journal of Andrology
Volume16
Issue number3
DOIs
StatePublished - May 1 2014

Keywords

  • Apatorsen
  • Apoptosis
  • Bcl-2 homologous antagonist-killer protein
  • Clusterin
  • Custirsen
  • Ganetespib
  • Heat-shock proteins
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

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