Heat shock (stress response) proteins and renal ischemia/reperfusion injury

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Citations (Scopus)

Abstract

Acute renal failure occurs frequently, may be increasing, carries an unacceptably high mortality, yet there is no specific treatment. The induction of stress response (heat shock) proteins (HSPs) is a highly conserved response that protects many cell types from diverse physiological and environmental stressors. HSP families of different sizes function as molecular chaperones that facilitate the folding of enzymes and other proteins into functional conformations. After injury, HSPs are believed to facilitate the restoration of normal function by assisting in the refolding of denatured proteins and degradation of irreparably damaged proteins and toxic metabolites, limitation of aggregation of damaged peptides and aiding appropriate folding of newly synthesized essential polypeptides. HSPs may also regulate apoptosis and immune functions. We have demonstrated protection from the functional deficits and histological evidence of experimental ischemic renal injury with heat stress 6 but not 48 h prior to ischemia. Limitation of the induction of HSPs (either with a short period of hyperthermia or pharmacologically) attenuated the protection observed. Other investigators have demonstrated a correlation between the levels of HSP25 and renal ischemic preconditioning in the mouse. Several pharmacological agents have been shown to increase HSP expression. Enhancement of these endogenous protective mechanisms has potential benefit in human disease.

Original languageEnglish
Title of host publicationContributions to Nephrology
Pages86-106
Number of pages21
Volume148
DOIs
StatePublished - 2005

Publication series

NameContributions to Nephrology
Volume148
ISSN (Print)03025144

Fingerprint

Heat-Shock Response
Heat-Shock Proteins
Reperfusion Injury
Kidney
Ischemic Preconditioning
Peptides
Molecular Chaperones
Poisons
Wounds and Injuries
Acute Kidney Injury
Proteolysis
Proteins
Fever
Ischemia
Hot Temperature
Research Personnel
Pharmacology
Apoptosis
Mortality
Enzymes

ASJC Scopus subject areas

  • Nephrology

Cite this

Kelly, K. (2005). Heat shock (stress response) proteins and renal ischemia/reperfusion injury. In Contributions to Nephrology (Vol. 148, pp. 86-106). (Contributions to Nephrology; Vol. 148). https://doi.org/10.1159/000086054

Heat shock (stress response) proteins and renal ischemia/reperfusion injury. / Kelly, Katherine.

Contributions to Nephrology. Vol. 148 2005. p. 86-106 (Contributions to Nephrology; Vol. 148).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kelly, K 2005, Heat shock (stress response) proteins and renal ischemia/reperfusion injury. in Contributions to Nephrology. vol. 148, Contributions to Nephrology, vol. 148, pp. 86-106. https://doi.org/10.1159/000086054
Kelly K. Heat shock (stress response) proteins and renal ischemia/reperfusion injury. In Contributions to Nephrology. Vol. 148. 2005. p. 86-106. (Contributions to Nephrology). https://doi.org/10.1159/000086054
Kelly, Katherine. / Heat shock (stress response) proteins and renal ischemia/reperfusion injury. Contributions to Nephrology. Vol. 148 2005. pp. 86-106 (Contributions to Nephrology).
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