Heat shock (stress response) proteins and renal ischemia/reperfusion injury

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Scopus citations


Acute renal failure occurs frequently, may be increasing, carries an unacceptably high mortality, yet there is no specific treatment. The induction of stress response (heat shock) proteins (HSPs) is a highly conserved response that protects many cell types from diverse physiological and environmental stressors. HSP families of different sizes function as molecular chaperones that facilitate the folding of enzymes and other proteins into functional conformations. After injury, HSPs are believed to facilitate the restoration of normal function by assisting in the refolding of denatured proteins and degradation of irreparably damaged proteins and toxic metabolites, limitation of aggregation of damaged peptides and aiding appropriate folding of newly synthesized essential polypeptides. HSPs may also regulate apoptosis and immune functions. We have demonstrated protection from the functional deficits and histological evidence of experimental ischemic renal injury with heat stress 6 but not 48 h prior to ischemia. Limitation of the induction of HSPs (either with a short period of hyperthermia or pharmacologically) attenuated the protection observed. Other investigators have demonstrated a correlation between the levels of HSP25 and renal ischemic preconditioning in the mouse. Several pharmacological agents have been shown to increase HSP expression. Enhancement of these endogenous protective mechanisms has potential benefit in human disease.

Original languageEnglish (US)
Title of host publicationCellular Stress Responses in Renal Diseases
EditorsM.S. Razzaque, M.S. Razzaque, T. Taguchi
Number of pages21
StatePublished - Dec 1 2005

Publication series

NameContributions to Nephrology
ISSN (Print)0302-5144

ASJC Scopus subject areas

  • Nephrology

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    Kelly, K. J. (2005). Heat shock (stress response) proteins and renal ischemia/reperfusion injury. In M. S. Razzaque, M. S. Razzaque, & T. Taguchi (Eds.), Cellular Stress Responses in Renal Diseases (pp. 86-106). (Contributions to Nephrology; Vol. 148). https://doi.org/10.1159/000086054