Hedgehog signaling in prostate cancer

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Prostate cancer is the most common malignancy and the second leading cancer-related cause of death in men in the USA. Despite enormous efforts in understanding the molecular basis of prostate cancer, very little progress has been made in prevention and treatment of this often lethal cancer. Recent studies have demonstrated that hedgehog signaling is frequently activated in advanced or metastatic prostate cancers. With small molecule inhibitors available to analyze the hedgehog signaling pathway, a novel rationale for prostate cancer therapy can be devised.

Original languageEnglish (US)
Pages (from-to)331-338
Number of pages8
JournalFuture Oncology
Volume1
Issue number3
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

Keywords

  • basal cell carcinoma
  • cyclopamine
  • patched gene
  • prostate specific antigen
  • small interfering RNA
  • smoothened
  • sonic hedgehog
  • suppressor of fused
  • transurethral resection of the prostate

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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